SHORT COMMUNICATIONHuman Cholecystokinin Type A Receptor Gene: Cytogenetic Localization, Physical Mapping, and Identification of Two Missense Variants in Patients with Obesity and Non-Insulin-Dependent Diabetes Mellitus (NIDDM)☆
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Cited by (45)
Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain
2011, NeuropeptidesCitation Excerpt :The relationship between this system and depression is not unknown as somatostatin 2 and 3 receptor agonists result in antidepressant-like effects in the forced swim test (Engin and Treit, 2009). CCKAR, on the other hand, has primarily been a target for understanding obesity (Inoue et al., 1997). Despite often suggestive findings, none of the four genes significantly altered by NGF (but not by the two established antidepressants) as compared with the saline controls is presently considered a primary candidate for depression etiology or antidepressant action.
Evidence of a Novel Quantitative-Trait Locus for Obesity on Chromosome 4p in Mexican Americans
2004, American Journal of Human GeneticsCitation Excerpt :In addition, CCK-like peptides are endogenous signals that are mediated by CCKA receptors, involved in the control of food intake in humans (Gutzwiller et al. 2000). Using a single-strand conformational polymorphism strategy, Inoue et al. (1997) identified five sequence variants, including two missense variants in patients with T2D and obesity, which may be influencing obesity and diabetes. Moran and coworkers (1998) showed that rats that do not express CCKA receptors develop obesity, hyperglycemia, and T2D.
Common gene polymorphisms and nutrition: Emerging links with pathogenesis of multifactorial chronic diseases (review)
2003, Journal of Nutritional BiochemistryA major predisposition locus for severe obesity, at 4p15-p14
2002, American Journal of Human GeneticsCitation Excerpt :The human draft genomic sequence around D4S3350 contains no obvious obesity-related candidate genes in the region (International Human Genome Sequencing Consortium 2001; Venter et al. 2001). Of the genes that previously have been implicated in obesity, CCKAR (cholecystokinin A receptor) (Ulrich et al. 1993; Miller et al. 1995; Inoue et al. 1997; Funakoshi et al. 2000) is the one closest to this region. However, in light of the position of this gene, we do not think that it will explain this linkage.
No association of CCK and CCK<inf>B</inf> receptor polymorphisms with alcohol dependence
2001, Psychiatry Research
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J. R. J. ReeveV. EysseleinT. E. SolomonV. L. W. Go, Eds.
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To whom correspondence should be addressed at the Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, 660 South Euclid, Campus Box 8127, St. Louis, MO 63110. Telephone: (314) 362-8680. Fax: (314) 362-4833. E-mail: [email protected].