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Endocrine FGFs and Klothos pp 214–228Cite as

FGF21 as a Therapeutic Reagent

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 728))

Abstract

The prevalence of obesity and diabetes has been dramatically increasing during the last decade suggesting a greater patient need for more efficacious and safer drugs. Large molecule therapy has played an important role in diabetes since the discovery of insulin. This legacy was continued upon the introduction of Humulin (first recombinant insulin), Humalog (first engineered insulin) and Byetta (first incretin mimetic). Several other protein therapeutics, such as leptin, adiponectin, bone morphogenic protein-9 and others, are currently in or considered for therapeutic development. Among them, FGF21 is one of the most promising candidates given its outstanding pharmacologic benefits for nearly each and every abnormality of a metabolic disease and lack of apparent side effects in a variety of animal models. Thus, FGF21 represents a novel and appealing therapeutic reagent for Type 2 diabetes mellitus, obesity, dyslipidemia, cardiovascular and fatty liver diseases. The in vitro biology, genetic animal models and in vivo pharmacology of FGF21 will be discussed in this chapter.

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Authors and Affiliations

  1. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA

    Yang Zhao, James D. Dunbar & Alexei Kharitonenkov

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  1. Yang Zhao
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  2. James D. Dunbar
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  3. Alexei Kharitonenkov
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Correspondence to Alexei Kharitonenkov .

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  1. Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    Makoto Kuro-o MD, PhD

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© 2012 Landes Bioscience and Springer Science+Business Media

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Zhao, Y., Dunbar, J.D., Kharitonenkov, A. (2012). FGF21 as a Therapeutic Reagent. In: Kuro-o, M. (eds) Endocrine FGFs and Klothos. Advances in Experimental Medicine and Biology, vol 728. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0887-1_14

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