Summary
Residual beta cell function was studied in 18 juvenile-onset diabetics by measuring serum C-peptide immunoreactivity (CPR) fasting, and after IV injection of glucagon (1 mg). This was compared with the exocrine pancreatic response to an IV infusion of secretin and cholecystokinin-pancreozymin. Outputs of pancreatic bicarbonate, amylase and trypsin were measured. Exocrine secretory pancreatic function was decreased in 14 patients. Fasting and maximal CPR showed that 9 patients had residual insulin secretion. For these ‘CPR-secretors’ there was a strong correlation between CPR and output of bicarbonate (r = 0.87, p < 0.005) and amylase (r =0.7, p < 0.05), but not with trypsin. These results suggest the existence of an endocrine-exocrine relationship in the pancreas.
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Frier, B.M., Faber, O.K., Binder, C. et al. The effect of residual insulin secretion on exocrine pancreatic function in juvenile-onset diabetes mellitus. Diabetologia 14, 301–304 (1978). https://doi.org/10.1007/BF01223020
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DOI: https://doi.org/10.1007/BF01223020