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Pathophysiological significance of adiponectin

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Abstract

Adipose tissue, which classically has been considered as an energy-storing organ, is now viewed as a massive source of bioactive substances such as leptin, tumor necrosis factor (TNF)-α, and adiponectin. Adiponectin was discovered to be the most abundant adipose-specific transcript. Its function had been unclear, but epidemiological and clinical studies have demonstrated that serum levels of adiponectin are inversely associated with body weight, especially abdominal visceral fat accumulation. In addition, adiponectin was inversely related to cardiovascular risk factors, such as insulin resistance, blood pressure, and low-density lipoprotein (LDL) cholesterol and triglyceride levels, and was positively related to high-density lipoprotein (HDL) cholesterol levels. Moreover, low adiponectin concentration is associated with a high incidence of cardiovascular disease (CVD), diabetes, some kinds of cancer, and other various diseases. These associations suggest the clinical significance of adiponectin, and a number of investigations are now being conducted to clarify the biological functions of adiponectin. Recent studies have revealed that adiponectin exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. In addition, adiponectin has been thought to be a key molecule in “metabolic syndrome,” which is an epidemiological target for preventing cardiovascular disease. Various functions of adiponectin may possibly serve to prevent and treat obesity-related diseases and CVD. Furthermore, enhancement of adiponectin secretion or action may become a promising therapeutic target.

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References

  1. K Maeda K Okubo I Shimomura T Funahashi Y Matsuzawa K Matsubara (1996) ArticleTitlecDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1) Biochem Biophys Res Commun 221 286–289 Occurrence Handle8619847 Occurrence Handle1:CAS:528:DyaK28XisVaht7s%3D

    PubMed  CAS  Google Scholar 

  2. K Maeda K Okubo I Shimomura K Mizuno Y Matsuzawa K Matsubara (1997) ArticleTitleAnalysis of an expression profile of genes in the human adipose tissue Gene (Amst) 190 227–235 Occurrence Handle1:CAS:528:DyaK2sXitl2ktL8%3D

    CAS  Google Scholar 

  3. T Funahashi T Nakamura I Shimomura K Maeda H Kuriyama M Takahashi Y Arita S Kihara Y Matsuzawa (1999) ArticleTitleRole of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity Intern Med 38 202–206 Occurrence Handle10225688 Occurrence Handle1:STN:280:DyaK1M3ktVaiug%3D%3D

    PubMed  CAS  Google Scholar 

  4. Y Nakano T Tobe NH Choi-Miura T Mazda M Tomita (1996) ArticleTitleIsolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma J Biochem (Tokyo) 120 803–812 Occurrence Handle1:CAS:528:DyaK28Xms1Wlsrs%3D

    CAS  Google Scholar 

  5. PE Scherer S Williams M Fogliano G Baldini HF Lodish (1995) ArticleTitleA novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 26746–26749 Occurrence Handle7592907 Occurrence Handle1:CAS:528:DyaK2MXpsVGmurY%3D

    PubMed  CAS  Google Scholar 

  6. E Hu P Liang BM Spiegelman (1996) ArticleTitleAdipoQ is a novel adipose-specific gene dysregulated in obesity J Biol Chem 271 10697–10703 Occurrence Handle8631877 Occurrence Handle1:CAS:528:DyaK28XivVaqtLw%3D

    PubMed  CAS  Google Scholar 

  7. Y Arita S Kihara N Ouchi M Takahashi K Maeda J Miyagawa K Hotta I Shimomura T Nakamura K Miyaoka H Kuriyama M Nishida S Yamashita K Okubo K Matsubara M Muraguchi Y Ohmoto T Funahashi Y Matsuzawa (1999) ArticleTitleParadoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 79–83 Occurrence Handle10092513 Occurrence Handle1:CAS:528:DyaK1MXhvF2is7w%3D

    PubMed  CAS  Google Scholar 

  8. M Takahashi Y Arita K Yamagata Y Matsukawa K Okutomi M Horie I Shimomura K Hotta H Kuriyama S Kihara T Nakamura S Yamashita T Funahashi Y Matsuzawa (2000) ArticleTitleGenomic structure and mutations in adipose-specific gene, adiponectin Int J Obes Relat Metab Disord 24 861–868 Occurrence Handle10918532 Occurrence Handle1:CAS:528:DC%2BD3cXlsFGlu7s%3D

    PubMed  CAS  Google Scholar 

  9. AH Kissebah GE Sonnenberg J Myklebust M Goldstein K Broman RG James JA Marks GR Krakower HJ Jacob J Weber L Martin J Blangero AG Comuzzie (2000) ArticleTitleQuantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome Proc Natl Acad Sci U S A 97 14478–14483 Occurrence Handle11121050 Occurrence Handle1:CAS:528:DC%2BD3MXitVCqsQ%3D%3D

    PubMed  CAS  Google Scholar 

  10. M Stumvoll O Tschritter A Fritsche H Staiger W Renn M Weisser F Machicao H Haring (2002) ArticleTitleAssociation of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes Diabetes 51 37–41 Occurrence Handle11756320 Occurrence Handle1:CAS:528:DC%2BD38Xlt1ejtA%3D%3D

    PubMed  CAS  Google Scholar 

  11. L Shapiro PE Scherer (1998) ArticleTitleThe crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor Curr Biol 8 335–338 Occurrence Handle9512423 Occurrence Handle1:CAS:528:DyaK1cXhvFaru7w%3D

    PubMed  CAS  Google Scholar 

  12. H Waki T Yamauchi J Kamon Y Ito S Uchida S Kita K Hara Y Hada F Vasseur P Froguel S Kimura R Nagai T Kadowaki (2003) ArticleTitleImpaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin J Biol Chem 278 40352–40363 Occurrence Handle12878598 Occurrence Handle1:CAS:528:DC%2BD3sXnvFamt7Y%3D

    PubMed  CAS  Google Scholar 

  13. UB Pajvani X Du TP Combs AH Berg MW Rajala T Schulthess J Engel M Brownlee PE Scherer (2003) ArticleTitleStructure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity J Biol Chem 278 9073–9085 Occurrence Handle12496257 Occurrence Handle1:CAS:528:DC%2BD3sXhvVyqu7g%3D

    PubMed  CAS  Google Scholar 

  14. Y Wang KS Lam L Chan KW Chan JB Lam MC Lam RC Hoo WW Mak GJ Cooper A Xu (2006) ArticleTitlePost-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex J Biol Chem 281 16391–16400 Occurrence Handle16621799 Occurrence Handle1:CAS:528:DC%2BD28XlsV2lsL8%3D

    PubMed  CAS  Google Scholar 

  15. J Fruebis TS Tsao S Javorschi D Ebbets-Reed MR Erickson FT Yen BE Bihain HF Lodish (2001) ArticleTitleProteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice Proc Natl Acad Sci U S A 98 2005–2010 Occurrence Handle11172066 Occurrence Handle1:CAS:528:DC%2BD3MXhsVWit78%3D

    PubMed  CAS  Google Scholar 

  16. K Hotta T Funahashi NL Bodkin HK Ortmeyer Y Arita BC Hansen Y Matsuzawa (2001) ArticleTitleCirculating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys Diabetes 50 1126–1133 Occurrence Handle11334417 Occurrence Handle1:CAS:528:DC%2BD3MXkvFSgu7g%3D

    PubMed  CAS  Google Scholar 

  17. T Yokota CS Meka KL Medina H Igarashi PC Comp M Takahashi M Nishida K Oritani J Miyagawa T Funahashi Y Tomiyama Y Matsuzawa PW Kincade (2002) ArticleTitleParacrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins J Clin Invest 109 1303–1310 Occurrence Handle12021245 Occurrence Handle1:CAS:528:DC%2BD38XjvFClsrg%3D

    PubMed  CAS  Google Scholar 

  18. HS Berner SP Lyngstadaas A Spahr M Monjo L Thommesen CA Drevon U Syversen JE Reseland (2004) ArticleTitleAdiponectin and its receptors are expressed in bone-forming cells Bone (NY) 35 842–849 Occurrence Handle1:CAS:528:DC%2BD2cXnvV2rtLo%3D

    CAS  Google Scholar 

  19. S Corbetta G Bulfamante D Cortelazzi V Barresi I Cetin G Mantovani S Bondioni P Beck-Peccoz A Spada (2005) ArticleTitleAdiponectin expression in human fetal tissues during mid- and late gestation J Clin Endocrinol Metab 90 2397–2402 Occurrence Handle15623813 Occurrence Handle1:CAS:528:DC%2BD2MXjsFWis7w%3D

    PubMed  CAS  Google Scholar 

  20. R Pineiro MJ Iglesias R Gallego K Raghay S Eiras J Rubio C Dieguez O Gualillo JR Gonzalez-Juanatey F Lago (2005) ArticleTitleAdiponectin is synthesized and secreted by human and murine cardiomyocytes FEBS Lett 579 5163–5169 Occurrence Handle16140297 Occurrence Handle1:CAS:528:DC%2BD2MXhtVehsrzO

    PubMed  CAS  Google Scholar 

  21. S Katsiougiannis EK Kapsogeorgou MN Manoussakis FN Skopouli (2006) ArticleTitleSalivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin Arthritis Rheum 54 2295–2299 Occurrence Handle16802369 Occurrence Handle1:CAS:528:DC%2BD28XnslKhu7Y%3D

    PubMed  CAS  Google Scholar 

  22. N Fujimoto N Matsuo H Sumiyoshi K Yamaguchi T Saikawa H Yoshimatsu H Yoshioka (2005) ArticleTitleAdiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos Biochim Biophys Acta 1731 1–12 Occurrence Handle16150499 Occurrence Handle1:CAS:528:DC%2BD2MXhtFektbbM

    PubMed  CAS  Google Scholar 

  23. JS Bogan HF Lodish (1999) ArticleTitleTwo compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4 J Cell Biol 146 609–620 Occurrence Handle10444069 Occurrence Handle1:CAS:528:DyaK1MXlt1erur4%3D

    PubMed  CAS  Google Scholar 

  24. L Xie D Boyle D Sanford PE Scherer JE Pessin S Mora (2006) ArticleTitleIntracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles J Biol Chem 281 7253–7259 Occurrence Handle16407204 Occurrence Handle1:CAS:528:DC%2BD28Xit1ygsbg%3D

    PubMed  CAS  Google Scholar 

  25. M Clarke MA Ewart LC Santy R Prekeris GW Gould (2006) ArticleTitleACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway Biochem Biophys Res Commun 342 1361–1367 Occurrence Handle16516854 Occurrence Handle1:CAS:528:DC%2BD28Xit1yntbg%3D

    PubMed  CAS  Google Scholar 

  26. L Feng P Arvan (2003) ArticleTitleThe trafficking of alpha 1-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells J Biol Chem 278 31486–31494 Occurrence Handle12796484 Occurrence Handle1:CAS:528:DC%2BD3sXmsVOnsbY%3D

    PubMed  CAS  Google Scholar 

  27. MD Turner P Arvan (2000) ArticleTitleProtein traffic from the secretory pathway to the endosomal system in pancreatic beta cells J Biol Chem 275 14025–14030 Occurrence Handle10799475 Occurrence Handle1:CAS:528:DC%2BD3cXjt1Cgtbs%3D

    PubMed  CAS  Google Scholar 

  28. CA Millar T Meerloo S Martin GR Hickson NJ Shimwell MJ Wakelam DE James GW Gould (2000) ArticleTitleAdipsin and the glucose transporter GLUT4 traffic to the cell surface via independent pathways in adipocytes Traffic 1 141–151 Occurrence Handle11208094 Occurrence Handle1:CAS:528:DC%2BD3cXktl2ms7s%3D

    PubMed  CAS  Google Scholar 

  29. G Fischer von Mollard B Stahl A Khokhlatchev TC Sudhof R Jahn (1994) ArticleTitleRab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis J Biol Chem 269 10971–10974 Occurrence Handle8157621 Occurrence Handle1:CAS:528:DyaK2cXis1KmsbY%3D

    PubMed  CAS  Google Scholar 

  30. M Zerial H McBride (2001) ArticleTitleRab proteins as membrane organizers Nat Rev Mol Cell Biol 2 107–117 Occurrence Handle11252952 Occurrence Handle1:CAS:528:DC%2BD3MXivVSitL8%3D

    PubMed  CAS  Google Scholar 

  31. JG Donaldson CL Jackson (2000) ArticleTitleRegulators and effectors of the ARF GTPases Curr Opin Cell Biol 12 475–482 Occurrence Handle10873831 Occurrence Handle1:CAS:528:DC%2BD3cXlt1Srur0%3D

    PubMed  CAS  Google Scholar 

  32. A Kessler E Tomas D Immler HE Meyer A Zorzano J Eckel (2000) ArticleTitleRab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin Diabetologia 43 1518–1527 Occurrence Handle11151761 Occurrence Handle1:CAS:528:DC%2BD3cXotFCrtrs%3D

    PubMed  CAS  Google Scholar 

  33. Y Aikawa TF Martin (2003) ArticleTitleARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis J Cell Biol 162 647–659 Occurrence Handle12925709 Occurrence Handle1:CAS:528:DC%2BD3sXms1Sqt78%3D

    PubMed  CAS  Google Scholar 

  34. FD Brown AL Rozelle HL Yin T Balla JG Donaldson (2001) ArticleTitlePhosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic J Cell Biol 154 1007–1017 Occurrence Handle11535619 Occurrence Handle1:CAS:528:DC%2BD3MXms1Slu7o%3D

    PubMed  CAS  Google Scholar 

  35. C D'Souza-Schorey G Li MI Colombo PD Stahl (1995) ArticleTitleA regulatory role for ARF6 in receptor-mediated endocytosis Science 267 1175–1178 Occurrence Handle7855600

    PubMed  Google Scholar 

  36. A Bose A Guilherme S Huang AC Hubbard CR Lane NA Soriano MP Czech (2005) ArticleTitleThe v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes J Biol Chem 280 36946–36951 Occurrence Handle16131485 Occurrence Handle1:CAS:528:DC%2BD2MXhtFKhtL3N

    PubMed  CAS  Google Scholar 

  37. AB Novikoff PM Novikoff OM Rosen CS Rubin (1980) ArticleTitleOrganelle relationships in cultured 3T3-L1 preadipocytes J Cell Biol 87 180–196 Occurrence Handle7191426 Occurrence Handle1:STN:280:Bi6D38nktlQ%3D

    PubMed  CAS  Google Scholar 

  38. T Yamauchi J Kamon Y Ito A Tsuchida T Yokomizo S Kita T Sugiyama M Miyagishi K Hara M Tsunoda K Murakami T Ohteki S Uchida S Takekawa H Waki NH Tsuno Y Shibata Y Terauchi P Froguel K Tobe S Koyasu K Taira T Kitamura T Shimizu R Nagai T Kadowaki (2003) ArticleTitleCloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature (Lond) 423 762–769 Occurrence Handle1:CAS:528:DC%2BD3sXksV2itL8%3D

    CAS  Google Scholar 

  39. K Kos AL Harte NF da Silva A Tontchev G Chalakov S James DR Snead B Hoggart JP O'hare PG McTernan S Kumar (2007) ArticleTitleAdiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus J Clin Endocrinol Metab 92 1129–1136 Occurrence Handle17213280 Occurrence Handle1:CAS:528:DC%2BD2sXjtlGmsLw%3D

    PubMed  CAS  Google Scholar 

  40. C Hug J Wang NS Ahmad JS Bogan TS Tsao HF Lodish (2004) ArticleTitleT-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin Proc Natl Acad Sci U S A 101 10308–10313 Occurrence Handle15210937 Occurrence Handle1:CAS:528:DC%2BD2cXmtVyku7c%3D

    PubMed  CAS  Google Scholar 

  41. ZY Huang Y Wu N Hedrick DH Gutmann (2003) ArticleTitleT-cadherin mediated cell growth regulation involves G2 phase arrest and requires p21 (CIP1/WAF1) expression Mol Cell Biol 23 566–578 Occurrence Handle12509455 Occurrence Handle1:CAS:528:DC%2BD3sXjslWqtg%3D%3D

    PubMed  CAS  Google Scholar 

  42. T Takeuchi A Misaki S-B Liang A Tachibana N Hayashi H Sonobe Y Ohtsuki (2000) ArticleTitleExpression of T-cadherin (CDH13, H-cadherin) in human brain and its characteristics as a negative growth regulator of EGF in neuroblastoma cells J Neurochem 74 1489–1497 Occurrence Handle10737605 Occurrence Handle1:CAS:528:DC%2BD3cXitVegt7o%3D

    PubMed  CAS  Google Scholar 

  43. AH Berg TP Combs X Du M Brownlee PE Scherer (2001) ArticleTitleThe adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 947–953 Occurrence Handle11479628 Occurrence Handle1:CAS:528:DC%2BD3MXlvVOktLw%3D

    PubMed  CAS  Google Scholar 

  44. WS Yang WJ Lee T Funahashi S Tanaka Y Matsuzawa CL Chao CL Chen TY Tai LM Chuang (2001) ArticleTitleWeight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin J Clin Endocrinol Metab 86 3815–3819 Occurrence Handle11502817 Occurrence Handle1:CAS:528:DC%2BD3MXlvFekurs%3D

    PubMed  CAS  Google Scholar 

  45. M Takahashi T Funahashi I Shimomura Y Miyaoka Y Matsuzawa (1996) ArticleTitlePlasma leptin levels and body fat distribution Horm Metab Res 28 751–752 Occurrence Handle9013757 Occurrence Handle1:CAS:528:DyaK2sXhtlOns74%3D

    PubMed  CAS  Google Scholar 

  46. M Cnop PJ Havel KM Utzschneider DB Carr MK Sinha EJ Boyko BM Retzlaff RH Knopp JD Brunzell SE Kahn (2003) ArticleTitleRelationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex Diabetologia 46 459–469 Occurrence Handle12687327 Occurrence Handle1:CAS:528:DC%2BD3sXjsFejsr8%3D

    PubMed  CAS  Google Scholar 

  47. T Yatagai S Nagasaka A Taniguchi M Fukushima T Nakamura A Kuroe Y Nakai S Ishibashi (2003) ArticleTitleHypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus Metabolism 52 1274–1278 Occurrence Handle14564678 Occurrence Handle1:CAS:528:DC%2BD3sXnvFSjtrg%3D

    PubMed  CAS  Google Scholar 

  48. N Maeda M Takahashi T Funahashi S Kihara H Nishizawa K Kishida H Nagaretani M Matsuda R Komuro N Ouchi H Kuriyama K Hotta T Nakamura I Shimomura Y Matsuzawa (2001) ArticleTitlePPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein Diabetes 50 2094–2099 Occurrence Handle11522676 Occurrence Handle1:CAS:528:DC%2BD3MXmsFKns7k%3D

    PubMed  CAS  Google Scholar 

  49. M Kumada S Kihara S Sumitsuji T Kawamoto S Matsumoto N Ouchi Y Arita Y Okamoto I Shimomura H Hiraoka T Nakamura Y Matsuzawa (2003) ArticleTitleAssociation of hypoadiponectinemia with coronary artery disease in men Arterioscler Thromb Vasc Biol 23 85–89 Occurrence Handle12524229 Occurrence Handle1:CAS:528:DC%2BD3sXhvFc%3D

    PubMed  CAS  Google Scholar 

  50. C Zoccali F Mallamaci G Tripepi FAQ Benedetto S Cutrupi S Parlongo LS Malatino G Monanno G Seminara F Rapisarda P Fatuzzo M Buemi G Nicocia S Tanaka S Kihara T Funahashi Y Matsuzawa (2002) ArticleTitleAdiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease J Am Soc Nephrol 13 134–141 Occurrence Handle11752030 Occurrence Handle1:CAS:528:DC%2BD38XltV2gsQ%3D%3D

    PubMed  CAS  Google Scholar 

  51. T Pischon CJ Girman GS Hotamisligil N Rifai FB Hu EB Rimm (2004) ArticleTitlePlasma adiponectin levels and risk of myocardial infarction in men JAMA 291 1730–1737 Occurrence Handle15082700 Occurrence Handle1:CAS:528:DC%2BD2cXjt1Wrt7Y%3D

    PubMed  CAS  Google Scholar 

  52. K Hotta T Funahashi Y Arita M Takahashi M Matsuda Y Okamoto H Iwahashi H Kuriyama N Ouchi K Maeda M Nishida S Kihara N Sakai T Nakajima K Hasegawa M Muraguchi Y Ohmoto T Nakamura S Yamashita T Hanafusa Y Matsuzawa (2000) ArticleTitlePlasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients Arterioscler Thromb Vasc Biol 20 1595–1599 Occurrence Handle10845877 Occurrence Handle1:CAS:528:DC%2BD3cXksVCgt7c%3D

    PubMed  CAS  Google Scholar 

  53. S Kojima T Funahashi H Maruyoshi O Honda S Sugiyama H Kawano H Soejima S Miyamoto J Hokamaki T Sakamoto M Yoshimura A Kitagawa Y Matsuzawa H Ogawa (2005) ArticleTitleLevels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma Thromb Res 115 483–490 Occurrence Handle15792679 Occurrence Handle1:CAS:528:DC%2BD2MXisFGlu7c%3D

    PubMed  CAS  Google Scholar 

  54. N Ouchi S Kihara Y Arita K Maeda H Kuriyama Y Okamoto K Hotta M Nishida M Takahashi T Nakamura S Yamashita T Funahashi Y Matsuzawa (1999) ArticleTitleNovel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin Circulation 100 2473–2476 Occurrence Handle10604883 Occurrence Handle1:CAS:528:DC%2BD3cXjvFSrsA%3D%3D

    PubMed  CAS  Google Scholar 

  55. Y Nakamura K Shimada D Fukuda Y Shimada S Ehara M Hirose T Kataoka K Kamimori S Shimodozono Y Kobayashi M Yoshiyama K Takeuchi J Yoshikawa (2004) ArticleTitleImplications of plasma concentrations of adiponectin in patients with coronary artery disease Heart 90 528–533 Occurrence Handle15084551 Occurrence Handle1:CAS:528:DC%2BD2cXktlKgu78%3D

    PubMed  CAS  Google Scholar 

  56. F Otsuka S Sugiyama S Kojima H Maruyoshi T Funahashi K Matsui T Sakamoto M Yoshimura K Kimura S Umemura H Ogawa (2006) ArticleTitlePlasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease J Am Coll Cardiol 48 1155–1162 Occurrence Handle16978998 Occurrence Handle1:CAS:528:DC%2BD28Xps1Cisbw%3D

    PubMed  CAS  Google Scholar 

  57. RS Lindsay T Funahashi RL Hanson Y Matsuzawa S Tanaka PA Tataranni WC Knowler J Krakoff (2002) ArticleTitleAdiponectin and development of type 2 diabetes in the Pima Indian population Lancet 360 57–58 Occurrence Handle12114044 Occurrence Handle1:CAS:528:DC%2BD38XltV2qs7Y%3D

    PubMed  CAS  Google Scholar 

  58. M Daimon T Oizumi T Saitoh W Kameda A Hirata H Yamaguchi H Ohnuma M Igarashi M Tominaga T Kato InstitutionalAuthorNameFunagata Study (2003) ArticleTitleDecreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: the Funagata study Diabetes Care 26 2015–2020 Occurrence Handle12832305 Occurrence Handle1:CAS:528:DC%2BD3sXlvFCjtbg%3D

    PubMed  CAS  Google Scholar 

  59. Y Yamamoto H Hirose I Saito K Nishikai T Saruta (2004) ArticleTitleAdiponectin, an adipocyte-derived protein, predicts future insulin resistance: two year follow-up study in Japanese population J Clin Endocrinol Metab 89 87–90 Occurrence Handle14715832 Occurrence Handle1:CAS:528:DC%2BD2cXmvFekuw%3D%3D

    PubMed  CAS  Google Scholar 

  60. C Snehalatha B Mukesh M Simon V Viswanathan SM Haffner A Ramachandran (2003) ArticleTitlePlasma adiponectin is an independent predictor of type 2 diabetes in Asian Indians Diabetes Care 26 3226–3229 Occurrence Handle14633806

    PubMed  Google Scholar 

  61. N Stefan B Vozarova T Funahashi Y Matsuzawa C Weyer RS Lindsay JF Youngren PJ Havel RE Pratley C Bogardus PA Tataranni (2002) ArticleTitlePlasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration and low plasma concentration precedes a decrease in whole body insulin sensitivity in humans Diabetes 51 1884–1888 Occurrence Handle12031977 Occurrence Handle1:CAS:528:DC%2BD38XktlSktbw%3D

    PubMed  CAS  Google Scholar 

  62. MB Snijder RJ Heine JC Seidell LM Bouter CD Stehouwer G Nijpels T Funahashi Y Matsuzawa I Shimomura JM Dekker (2006) ArticleTitleAssociations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the Hoorn study Diabetes Care 29 2498–2503 Occurrence Handle17065691 Occurrence Handle1:CAS:528:DC%2BD28Xht1GktbfN

    PubMed  CAS  Google Scholar 

  63. M Adamczak A Wiecek T Funahashi J Chudek F Kokot Y Matsuzawa (2003) ArticleTitleDecreased plasma adiponectin concentration in patients with essential hypertension Am J Hypertens 16 72–75 Occurrence Handle12517687 Occurrence Handle1:CAS:528:DC%2BD3sXhtVyks7o%3D

    PubMed  CAS  Google Scholar 

  64. Y Iwashima T Katsuya K Ishikawa N Ouchi M Ohishi K Sugimoto Y Fu M Motone K Yamamoto A Matsuo K Ohashi S Kihara T Funahashi H Rakugi Y Matsuzawa T Ogihara (2004) ArticleTitleHypoadiponectinemia is an independent risk factor for hypertension Hypertension 43 1318–1323 Occurrence Handle15123570 Occurrence Handle1:CAS:528:DC%2BD2cXktFSlu78%3D

    PubMed  CAS  Google Scholar 

  65. F Mallamaci C Zoccali F Cuzzola G Tripepi S Cutrupi S Parlongo S Tanaka N Ouchi S Kihara T Funahashi Y Matsuzawa (2002) ArticleTitleAdiponectin and essential hypertension J Nephrol 15 507–511 Occurrence Handle12455716 Occurrence Handle1:CAS:528:DC%2BD38Xpsl2ksLw%3D

    PubMed  CAS  Google Scholar 

  66. K Ohashi S Kihara N Ouchi M Kumada K Fujita A Hiuge T Hibuse M Ryo H Nishizawa N Maeda K Maeda R Shibata K Walsh T Funahashi I Shimomura (2006) ArticleTitleAdiponectin replenishment ameliorates obesity-related hypertension Hypertension 47 1108–1116 Occurrence Handle16651465 Occurrence Handle1:CAS:528:DC%2BD28XksVOmu7Y%3D

    PubMed  CAS  Google Scholar 

  67. M Matsubara S Maruoka S Katayose (2002) ArticleTitleDecreased plasma adiponectin concentrations in women with dyslipidemia J Clin Endocrinol Metab 87 2764–2769 Occurrence Handle12050247 Occurrence Handle1:CAS:528:DC%2BD38XkvFakur8%3D

    PubMed  CAS  Google Scholar 

  68. T Kazumi A Kawaguchi K Sakai T Hirano G Yoshino (2002) ArticleTitleYoung men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure Diabetes Care 25 971–976 Occurrence Handle12032101

    PubMed  Google Scholar 

  69. J Hulthe LM Hulten B Fagerberg (2003) ArticleTitleLow adipocyte-derived plasma protein adiponectin concentrations are associated with the metabolic syndrome and small dense low-density lipoprotein particles: atherosclerosis and insulin resistance study Metabolism 52 1612–1614 Occurrence Handle14669165 Occurrence Handle1:CAS:528:DC%2BD3sXpsVSmsro%3D

    PubMed  CAS  Google Scholar 

  70. B Zietz H Herfarth G Paul A Ehling U Muller-Ladner J Scholmerich A Schaffler (2003) ArticleTitleAdiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes FEBS Lett 545 103–104 Occurrence Handle12804757 Occurrence Handle1:CAS:528:DC%2BD3sXksVOksLw%3D

    PubMed  CAS  Google Scholar 

  71. MB Schulze EB Rimm I Shai N Rifai FB Hu (2004) ArticleTitleRelationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes Diabetes Care 27 1680–1687 Occurrence Handle15220246 Occurrence Handle1:CAS:528:DC%2BD2cXmt1Cmt7Y%3D

    PubMed  CAS  Google Scholar 

  72. M Neumeier A Sigruener E Eggenhofer J Weigert TS Weiss A Schaeffler HJ Schlitt C Aslanidis P Piso T Langmann G Schmitz J Scholmerich C Buechler (2007) ArticleTitleHigh molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes Biochem Biophys Res Commun 352 543–548 Occurrence Handle17129575 Occurrence Handle1:CAS:528:DC%2BD28XhtlShsrrO

    PubMed  CAS  Google Scholar 

  73. KM Choi J Lee KW Lee JA Seo JH Oh SG Kim NH Kim DS Choi SH Baik (2004) ArticleTitleSerum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans Clin Endocrinol (Oxf) 61 75–80 Occurrence Handle1:CAS:528:DC%2BD2cXmslKitbk%3D

    CAS  Google Scholar 

  74. M Ryo T Nakamura S Kihara M Kumada S Shibazaki M Takahashi M Nagai Y Matsuzawa T Funahashi (2004) ArticleTitleAdiponectin as a biomarker of the metabolic syndrome Circ J 68 975–981 Occurrence Handle15502375 Occurrence Handle1:CAS:528:DC%2BD2cXhtFakur7N

    PubMed  CAS  Google Scholar 

  75. K Ohashi N Ouchi S Kihara T Funahashi T Nakamura S Sumitsuji T Kawamoto S Matsumoto H Nagaretani M Kumada Y Okamoto H Nishizawa K Kishida N Maeda H Hiraoka Y Iwashima K Ishikawa M Ohishi T Katsuya H Rakugi T Ogihara Y Matsuzawa (2004) ArticleTitleAdiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease J Am Coll Cardiol 43 1195–1200 Occurrence Handle15063429 Occurrence Handle1:CAS:528:DC%2BD2cXjvFeis7k%3D

    PubMed  CAS  Google Scholar 

  76. S Engeli M Feldpausch K Gorzelniak F Hartwig U Heintze J Janke M Mohlig AF Pfeiffer FC Luft AM Sharma (2003) ArticleTitleAssociation between adiponectin and mediators of inflammation in obese women Diabetes 52 942–947 Occurrence Handle12663465 Occurrence Handle1:CAS:528:DC%2BD3sXislOnsrc%3D

    PubMed  CAS  Google Scholar 

  77. N Ouchi S Kihara T Funahashi T Nakamura M Nishida M Kumada Y Okamoto K Ohashi H Nagaretani K Kishida H Nishizawa N Maeda H Kobayashi H Hiraoka Y Matsuzawa (2003) ArticleTitleReciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue Circulation 107 671–674 Occurrence Handle12578865 Occurrence Handle1:CAS:528:DC%2BD3sXot12juw%3D%3D

    PubMed  CAS  Google Scholar 

  78. J Krakoff T Funahashi CD Stehouwer CG Schalkwijk S Tanaka Y Matsuzawa S Kobes PA Tataranni RL Hanson WC Knowler RS Lindsay (2003) ArticleTitleInflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian Diabetes Care 26 1745–1751 Occurrence Handle12766104 Occurrence Handle1:CAS:528:DC%2BD3sXkslKrtLs%3D

    PubMed  CAS  Google Scholar 

  79. M Matsubara K Namioka S Katayose (2003) ArticleTitleDecreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevation Eur J Endocrinol 148 657–662 Occurrence Handle12773138 Occurrence Handle1:CAS:528:DC%2BD3sXkvFSjur4%3D

    PubMed  CAS  Google Scholar 

  80. PA Kern GB Di Gregorio T Lu N Rassouli G Ranganathan (2003) ArticleTitleAdiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression Diabetes 52 1779–1785 Occurrence Handle12829646 Occurrence Handle1:CAS:528:DC%2BD3sXltlWhtbk%3D

    PubMed  CAS  Google Scholar 

  81. K Yamamoto T Kiyohara Y Murayama S Kihara Y Okamoto T Funahashi T Ito R Nezu S Tsutsui JI Miyagawa S Tamura Y Matsuzawa I Shimomura Y Shinomura (2005) ArticleTitleProduction of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease Gut 54 789–796 Occurrence Handle15888786 Occurrence Handle1:CAS:528:DC%2BD2MXltlOmsbo%3D

    PubMed  CAS  Google Scholar 

  82. L Senolt K Pavelka D Housa M Haluzik (2006) ArticleTitleIncreased adiponectin is negatively linked to the local inflammatory process in patients with rheumatoid arthritis Cytokine 35 247–252 Occurrence Handle17079158 Occurrence Handle1:CAS:528:DC%2BD28Xht1KltrnJ

    PubMed  CAS  Google Scholar 

  83. I Kelesidis T Kelesidis CS Mantzoros (2006) ArticleTitleAdiponectin and cancer: a systematic review Br J Cancer 94 1221–1225 Occurrence Handle16570048 Occurrence Handle1:CAS:528:DC%2BD28XktVahsbo%3D

    PubMed  CAS  Google Scholar 

  84. D Housa J Housova Z Vernerova M Haluzik (2005) ArticleTitleAdipocytokines and cancer Physiol Res 55 233–244 Occurrence Handle16238454

    PubMed  Google Scholar 

  85. E Petridou C Mantzoros N Dessypris P Koukoulomatis C Addy Z Voulgaris G Chrousos D Trichopoulos (2003) ArticleTitlePlasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece J Clin Endocrinol Metab 88 993–997 Occurrence Handle12629074 Occurrence Handle1:CAS:528:DC%2BD3sXit1egtb0%3D

    PubMed  CAS  Google Scholar 

  86. L Dal Maso LS Augustin A Karalis R Talamini S Franceschi D Trichopoulos CS Mantzoros C La Vecchia (2004) ArticleTitleCirculating adiponectin and endometrial cancer risk J Clin Endocrinol Metab 89 1160–1163 Occurrence Handle15001602 Occurrence Handle1:CAS:528:DC%2BD2cXisVWrur8%3D

    PubMed  CAS  Google Scholar 

  87. AE Cust R Kaaks C Friedenreich F Bonnet M Laville A Lukanova S Rinaldi L Dossus N Slimani E Lundin A Tjonneland A Olsen K Overvad F Clavel-Chapelon S Mesrine V Joulin J Linseisen S Rohrmann T Pischon H Boeing D Trichopoulos A Trichopoulou V Benetou D Palli F Berrino R Tumino C Sacerdote A Mattiello JR Quiros MA Mendez MJ Sanchez N Larranaga MJ Tormo E Ardanaz HB Bueno-de-Mesquita PH Peeters CH van Gils KT Khaw S Bingham N Allen T Key M Jenab E Riboli (2007) ArticleTitlePlasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women J Clin Endocrinol Metab 92 255–263 Occurrence Handle17062769 Occurrence Handle1:CAS:528:DC%2BD2sXpsVKhtA%3D%3D

    PubMed  CAS  Google Scholar 

  88. C Mantzoros E Petridou N Dessypris C Chavelas M Dalamaga DM Alexe Y Papadiamantis C Markopoulos E Spanos G Chrousos D Trichopoulos (2004) ArticleTitleAdiponectin and breast cancer risk J Clin Endocrinol Metab 89 1102–1107 Occurrence Handle15001594 Occurrence Handle1:CAS:528:DC%2BD2cXisVWrtbw%3D

    PubMed  CAS  Google Scholar 

  89. SS Tworoger AH Eliassen T Kelesidis GA Colditz WC Willett C Mantzoros SE Hankinson (2007) ArticleTitlePlasma adiponectin concentrations and risk of incident breast cancer J Clin Endocrinol Metab 92 1510–1516 Occurrence Handle17213279

    PubMed  Google Scholar 

  90. E Wei E Giovannucci C Fuchs W Wilett CS Mantzoros (2005) ArticleTitlePlasma adiponectin levels and the risk of colorectal cancer in men JNCI 97 1688–1694 Occurrence Handle16288122 Occurrence Handle1:CAS:528:DC%2BD2MXht1entb7J

    PubMed  CAS  Google Scholar 

  91. S Otake H Takeda Y Suzuki T Fukui S Watanabe K Ishihama T Saito H Togashi T Nakamura Y Matsuzawa S Kawata (2005) ArticleTitleAssociation of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance Clin Cancer Res 11 3642–3646 Occurrence Handle15897559 Occurrence Handle1:CAS:528:DC%2BD2MXktFyrsbw%3D

    PubMed  CAS  Google Scholar 

  92. M Ishikawa J Kitayama S Kazama T Hiramatsu K Hatano H Nagawa (2005) ArticleTitlePlasma adiponectin and gastric cancer Clin Cancer Res 11 466–472 Occurrence Handle15701829 Occurrence Handle1:CAS:528:DC%2BD2MXislWgtrc%3D

    PubMed  CAS  Google Scholar 

  93. S Goktas MI Yilmaz K Caglar A Sonmez S Kilic S Bedir (2005) ArticleTitleProstate cancer and adiponectin Urology 65 1168–1172 Occurrence Handle15922427

    PubMed  Google Scholar 

  94. E Petridou CS Mantzoros N Dessypris SK Dikalioti D Trichopoulos (2006) ArticleTitleAdiponectin in relation to childhood myeloblastic leukaemia Br J Cancer 94 156–160 Occurrence Handle16404369 Occurrence Handle1:CAS:528:DC%2BD28XisVGhug%3D%3D

    PubMed  CAS  Google Scholar 

  95. E Brakenhielm N Veitonmaki R Cao S Kihara Y Matsuzawa B Zhivotovsky T Funahashi Y Cao (2004) ArticleTitleAdiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis Proc Natl Acad Sci U S A 10 2476–2481

    Google Scholar 

  96. JB Richards AM Valdes K Burling UC Perks TD Spector (2007) ArticleTitleSerum adiponectin and bone mineral density in women J Clin Endocrinol Metab 92 1517–1523 Occurrence Handle17264180 Occurrence Handle1:CAS:528:DC%2BD2sXksVSrtbw%3D

    PubMed  CAS  Google Scholar 

  97. Y Okamoto Y Arita M Nishida M Muraguchi N Ouchi M Takahashi T Igura Y Inui S Kihara T Nakamura S Yamashita J Miyagawa T Funahashi Y Matsuzawa (2000) ArticleTitleAn adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls Horm Metab Res 32 47–50 Occurrence Handle10741683 Occurrence Handle1:CAS:528:DC%2BD3cXisVygs7w%3D

    PubMed  CAS  Google Scholar 

  98. M Shimabukuro N Higa T Asahi Y Oshiro N Takasu T Tagawa S Ueda I Shimomura T Funahashi Y Matsuzawa (2003) ArticleTitleHypoadiponectinemia is closely linked to endothelial dysfunction in man J Clin Endocrinol Metab 88 3236–3240 Occurrence Handle12843170 Occurrence Handle1:CAS:528:DC%2BD3sXlslaitL0%3D

    PubMed  CAS  Google Scholar 

  99. KC Tan A Xu WS Chow MC Lam VH Ai SC Tam KS Lam (2004) ArticleTitleHypoadiponectinemia is associated with impaired endothelium-dependent vasodilation J Clin Endocrinol Metab 89 765–769 Occurrence Handle14764794 Occurrence Handle1:CAS:528:DC%2BD2cXhsFOjtrs%3D

    PubMed  CAS  Google Scholar 

  100. H Chen M Montagnani T Funahashi I Shimomura MJ Quon (2003) ArticleTitleAdiponectin stimulates production of nitric oxide in vascular endothelial cells J Biol Chem 278 45021–45026 Occurrence Handle12944390 Occurrence Handle1:CAS:528:DC%2BD3sXoslWlt7s%3D

    PubMed  CAS  Google Scholar 

  101. H Motoshima X Wu K Mahadev BJ Goldstein (2004) ArticleTitleAdiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL Biochem Biophys Res Commun 315 264–271 Occurrence Handle14766203 Occurrence Handle1:CAS:528:DC%2BD2cXps1OhsA%3D%3D

    PubMed  CAS  Google Scholar 

  102. N Ouchi M Ohishi S Kihara T Funahashi T Nakamura H Nagaretani M Kumada K Ohashi Y Okamoto H Nishizawa K Kishida N Maeda A Nagasawa H Kobayashi H Hiraoka N Komai M Kaibe H Rakugi T Ogihara Y Matsuzawa (2003) ArticleTitleAssociation of hypoadiponectinemia with impaired vasoreactivity Hypertension 42 231–234 Occurrence Handle12860835 Occurrence Handle1:CAS:528:DC%2BD3sXmslSjurw%3D

    PubMed  CAS  Google Scholar 

  103. N Ouchi S Kihara Y Arita M Nishida A Matsuyama Y Okamoto M Ishigami H Kuriyama K Kishida H Nishizawa K Hotta M Muraguchi Y Ohmoto S Yamashita T Funahashi Y Matsuzawa (2001) ArticleTitleAdipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages Circulation 103 1057–1063 Occurrence Handle11222466 Occurrence Handle1:CAS:528:DC%2BD3MXisFent74%3D

    PubMed  CAS  Google Scholar 

  104. M Kumada S Kihara N Ouchi H Kobayashi Y Okamoto K Ohashi K Maeda H Nagaretani K Kishida N Maeda A Nagasawa T Funahashi Y Matsuzawa (2004) ArticleTitleAdiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages Circulation 109 2046–2049 Occurrence Handle15096450 Occurrence Handle1:CAS:528:DC%2BD2cXjsVWqsrg%3D

    PubMed  CAS  Google Scholar 

  105. Y Arita S Kihara N Ouchi K Maeda H Kuriyama Y Okamoto M Kumada K Hotta M Nishida M Takahashi T Nakamura I Shimomura M Muraguchi Y Ohmoto T Funahashi Y Matsuzawa (2002) ArticleTitleAdipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell Circulation 105 2893–2898 Occurrence Handle12070119 Occurrence Handle1:CAS:528:DC%2BD38Xls1aku7o%3D

    PubMed  CAS  Google Scholar 

  106. Y Matsuzawa T Funahashi S Kihara I Shimomura (2004) ArticleTitleAdiponectin and metabolic syndrome Arterioscler Thromb Vasc Biol 24 29–33 Occurrence Handle14551151 Occurrence Handle1:CAS:528:DC%2BD3sXhtVWhurvK

    PubMed  CAS  Google Scholar 

  107. H Kato H Kashiwagi M Shiraga S Tadokoro T Kamae H Ujiie S Honda S Miyata Y Ijiri J Yamamoto N Maeda T Funahashi Y Kurata I Shimomura Y Tomiyama Y Kanakura (2006) ArticleTitleAdiponectin acts as an endogenous antithrombotic factor Arterioscler Thromb Vasc Biol 26 224–230 Occurrence Handle16269667 Occurrence Handle1:CAS:528:DC%2BD2MXhtlagt7jK

    PubMed  CAS  Google Scholar 

  108. R Shibata K Sato DR Pimentel Y Takemura S Kihara K Ohashi T Funahashi N Ouchi K Walsh (2005) ArticleTitleAdiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms Nat Med 11 1096–1103 Occurrence Handle16155579 Occurrence Handle1:CAS:528:DC%2BD2MXhtVOiurfK

    PubMed  CAS  Google Scholar 

  109. R Shibata N Ouchi M Ito S Kihara I Shiojima DR Pimentel M Kumada K Sato S Schiekofer K Ohashi T Funahashi WS Colucci K Walsh (2004) ArticleTitleAdiponectin-mediated modulation of hypertrophic signals in the heart Nat Med 10 1384–1389 Occurrence Handle15558058 Occurrence Handle1:CAS:528:DC%2BD2cXhtVCisbfL

    PubMed  CAS  Google Scholar 

  110. TP Combs AH Berg S Obici PE Scherer L Rossetti (2001) ArticleTitleEndogenous glucose production is inhibited by the adipose-derived protein Acrp30 J Clin Invest 108 1875–1881 Occurrence Handle11748271 Occurrence Handle1:CAS:528:DC%2BD3MXpt1SjsL8%3D

    PubMed  CAS  Google Scholar 

  111. T Yamauchi J Kamon Y Minokoshi Y Ito H Waki S Uchida S Yamashita M Noda S Kita K Ueki K Eto Y Akanuma P Froguel F Foufelle P Ferre D Carling S Kimura R Nagai BB Kahn T Kadowaki (2002) ArticleTitleAdiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 1288–1295 Occurrence Handle12368907 Occurrence Handle1:CAS:528:DC%2BD38XotlWlsrg%3D

    PubMed  CAS  Google Scholar 

  112. N Stefan M Stumvoll B Vozarova C Weyer T Funahashi Y Matsuzawa C Bogardus PA Tataranni (2003) ArticleTitlePlasma adiponectin and endogenous glucose production in humans Diabetes Care 26 3315–3319 Occurrence Handle14633820 Occurrence Handle1:CAS:528:DC%2BD3sXpvF2ksL0%3D

    PubMed  CAS  Google Scholar 

  113. J Fruebis TS Tsao S Javorschi D Ebbets-Reed MR Erickson FT Yen BE Bihain HF Lodish (2001) ArticleTitleProteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice Proc Natl Acad Sci U S A 98 2005–2010 Occurrence Handle11172066 Occurrence Handle1:CAS:528:DC%2BD3MXhsVWit78%3D

    PubMed  CAS  Google Scholar 

  114. T Yamauchi J Kamon H Waki Y Terauchi N Kubota K Hara Y Mori T Ide K Murakami N Tsuboyama-Kasaoka O Ezaki Y Akanuma O Gavrilova C Vinson ML Reitman H Kagechika K Shudo M Yoda Y Nakano K Tobe R Nagai S Kimura M Tomita P Froguel T Kadowaki (2001) ArticleTitleThe fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat Med 7 941–946 Occurrence Handle11479627 Occurrence Handle1:CAS:528:DC%2BD3MXlvVOkt7o%3D

    PubMed  CAS  Google Scholar 

  115. E Tomas TS Tsao AK Saha HE Murrey CC Zhang SI Itani HF Lodish NB Ruderman (2002) ArticleTitleEnhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation Proc Natl Acad Sci U S A 99 16309–16313 Occurrence Handle12456889 Occurrence Handle1:CAS:528:DC%2BD38Xps1ent78%3D

    PubMed  CAS  Google Scholar 

  116. N Maeda I Shimomura K Kishida H Nishizawa M Matsuda H Nagaretani N Furuyama H Kondo M Takahashi Y Arita R Komuro N Ouchi S Kihara Y Tochino K Okutomi M Horie S Takeda T Aoyama T Funahashi Y Matsuzawa (2002) ArticleTitleDiet-induced insulin resistance in mice lacking adiponectin/ACRP30 Nat Med 8 731–737 Occurrence Handle12068289 Occurrence Handle1:CAS:528:DC%2BD38XkvFehtr8%3D

    PubMed  CAS  Google Scholar 

  117. T Yamauchi Y Nio T Maki M Kobayashi T Takazawa M Iwabu M Okada-Iwabu S Kawamoto N Kubota T Kubota Y Ito J Kamon A Tsuchida K Kumagai H Kozono Y Hada H Ogata K Tokuyama M Tsunoda T Ide K Murakami M Awazawa I Takamoto P Froguel K Hara K Tobe R Nagai K Ueki T Kadowaki (2007) ArticleTitleTargeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 332–339 Occurrence Handle17268472 Occurrence Handle1:CAS:528:DC%2BD2sXisVKku7g%3D

    PubMed  CAS  Google Scholar 

  118. C Wang X Mao L Wang M Liu MD Wetzel KL Guan LQ Dong F Liu (2007) ArticleTitleAdiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1 J Biol Chem 282 7991–7996 Occurrence Handle17244624 Occurrence Handle1:CAS:528:DC%2BD2sXis1Kgtrg%3D

    PubMed  CAS  Google Scholar 

  119. Y Okamoto S Kihara N Ouchi M Nishida Y Arita M Kumada K Ohashi N Sakai I Shimomura H Kobayashi N Terasaka T Inaba T Funahashi Y Matsuzawa (2002) ArticleTitleAdiponectin reduces atherosclerosis in apolipoprotein E-deficient mice Circulation 106 2767–2770 Occurrence Handle12451000 Occurrence Handle1:CAS:528:DC%2BD38XoslSnsbw%3D

    PubMed  CAS  Google Scholar 

  120. N Ouchi S Kihara Y Arita Y Okamoto K Maeda H Kuriyama K Hotta M Nishida M Takahashi M Muraguchi Y Ohmoto T Nakamura S Yamashita T Funahashi Y Matsuzawa (2000) ArticleTitleAdiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 1296–1301 Occurrence Handle10982546 Occurrence Handle1:CAS:528:DC%2BD3cXntFCgt7g%3D

    PubMed  CAS  Google Scholar 

  121. Y Takemura N Ouchi R Shibata T Aprahamian MT Kirber RS Summer S Kihara K Walsh (2007) ArticleTitleAdiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies J Clin Invest 117 375–386 Occurrence Handle17256056 Occurrence Handle1:CAS:528:DC%2BD2sXhs1Oqtr4%3D

    PubMed  CAS  Google Scholar 

  122. RW Vandivier CA Ogden VA Fadok PR Hoffmann KK Brown M Botto MJ Walport JH Fisher (2002) ArticleTitleRole of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex J Immunol 169 3978–3986 Occurrence Handle12244199 Occurrence Handle1:CAS:528:DC%2BD38XnsFelurw%3D

    PubMed  CAS  Google Scholar 

  123. TS Tsao HE Murrey C Hug DH Lee HF Lodish (2002) ArticleTitleOligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30) J Biol Chem 277 29359–29362 Occurrence Handle12087086 Occurrence Handle1:CAS:528:DC%2BD38XmsVKisbs%3D

    PubMed  CAS  Google Scholar 

  124. T Nishihara M Matsuda H Araki K Oshima S Kihara T Funahashi I Shimomura (2006) ArticleTitleEffect of adiponectin on murine colitis induced by dextran sulfate sodium Gastroenterology 131 853–861 Occurrence Handle16952554 Occurrence Handle1:CAS:528:DC%2BD28XhtVKrurnJ

    PubMed  CAS  Google Scholar 

  125. Y Kamada S Tamura S Kiso H Matsumoto Y Saji Y Yoshida K Fukui N Maeda H Nishizawa H Nagaretani Y Okamoto S Kihara J Miyagawa Y Shinomura T Funahashi Y Matsuzawa (2003) ArticleTitleEnhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin Gastroenterology 125 1796–1807 Occurrence Handle14724832 Occurrence Handle1:CAS:528:DC%2BD2cXhtVOqtg%3D%3D

    PubMed  CAS  Google Scholar 

  126. H Matsumoto S Tamura Y Kamada S Kiso J Fukushima A Wada N Maeda S Kihara T Funahashi Y Matsuzawa I Shimomura N Hayashi (2006) ArticleTitleAdiponectin deficiency exacerbates lipopolysaccharide/-galactosamine-induced liver injury in mice World J Gastroenterol 12 3352–3358 Occurrence Handle16733851 Occurrence Handle1:CAS:528:DC%2BD28XnsFWktL8%3D

    PubMed  CAS  Google Scholar 

  127. SA Shore RD Terry L Flynt A Xu C Hug (2006) ArticleTitleAdiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice J Allergy Clin Immunol 118 389–395 Occurrence Handle16890763 Occurrence Handle1:CAS:528:DC%2BD28Xot1Wrsbo%3D

    PubMed  CAS  Google Scholar 

  128. PW Peake Y Shen LV Campbell JA Charlesworth (2006) ArticleTitleHuman adiponectin binds to bacterial lipopolysaccharide Biochem Biophys Res Commun 341 108–115 Occurrence Handle16431217 Occurrence Handle1:CAS:528:DC%2BD28XoslOrtw%3D%3D

    PubMed  CAS  Google Scholar 

  129. N Kubota Y Terauchi T Yamauchi T Kubota M Moroi J Matsui K Eto T Yamashita J Kamon H Satoh W Yano P Froguel R Nagai S Kimura T Kadowaki T Noda (2002) ArticleTitleDisruption of adiponectin causes insulin resistance and neointimal formation J Biol Chem 277 25863–25866 Occurrence Handle12032136 Occurrence Handle1:CAS:528:DC%2BD38XlsFKrs7o%3D

    PubMed  CAS  Google Scholar 

  130. M Matsuda I Shimomura M Sata Y Arita M Nishida N Maeda M Kumada Y Okamoto H Nagaretani H Nishizawa K Kishida R Komuro N Ouchi S Kihara R Nagai T Funahashi Y Matsuzawa (2002) ArticleTitleRole of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis J Biol Chem 277 37487–37491 Occurrence Handle12138120 Occurrence Handle1:CAS:528:DC%2BD38XnsVejs7o%3D

    PubMed  CAS  Google Scholar 

  131. JG Yu S Javorschi AL Hevener YT Kruszynska RA Norman M Sinha JM Olefsky (2002) ArticleTitleThe effect of thiazolidinedione on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects Diabetes 51 2968–2974 Occurrence Handle12351435 Occurrence Handle1:CAS:528:DC%2BD38XnslGhs7w%3D

    PubMed  CAS  Google Scholar 

  132. WS Yang CY Jeng TJ Wu S Tanaka T Funahashi Y Matsuzawa JP Wang CL Chen TY Tai LM Chuang (2002) ArticleTitleSynthetic peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients Diabetes Care 25 376–380 Occurrence Handle11815513 Occurrence Handle1:CAS:528:DC%2BD38Xhtlyks7s%3D

    PubMed  CAS  Google Scholar 

  133. J Tonelli W Li P Kishore UB Pajvani E Kwon C Weaver PE Scherer M Hawkins (2004) ArticleTitleMechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes Diabetes 53 1621–1629 Occurrence Handle15161771 Occurrence Handle1:CAS:528:DC%2BD2cXkslCgsb4%3D

    PubMed  CAS  Google Scholar 

  134. AM Bodles A Banga N Rasouli F Ono PA Kern RJ Owens (2006) ArticleTitlePioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes Am J Physiol Endocrinol Metab 291 E1100–E1105 Occurrence Handle16803857 Occurrence Handle1:CAS:528:DC%2BD28Xht1GnsL7O

    PubMed  CAS  Google Scholar 

  135. A Hiuge A Tenenbaum N Maeda M Benderly M Kumada EZ Fisman D Tanne Z Matas T Hibuse K Fujita H Nishizawa Y Adler M Motro S Kihara I Shimomura S Behar T Funahashi (2006) ArticleTitleEffects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level Arterioscler Thromb Vasc Biol 27 635–641 Occurrence Handle17194889

    PubMed  Google Scholar 

  136. G Chinetti C Zawadski JC Fruchart B Staels (2004) ArticleTitleExpression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR Biochem Biophys Res Commun 314 151–158 Occurrence Handle14715259 Occurrence Handle1:CAS:528:DC%2BD2cXjtVejtw%3D%3D

    PubMed  CAS  Google Scholar 

  137. M Iwaki M Matsuda N Maeda T Funahashi Y Matsuzawa M Makishima I Shimomura (2003) ArticleTitleInduction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors Diabetes 52 1655–1663 Occurrence Handle12829629 Occurrence Handle1:CAS:528:DC%2BD3sXltlWhtL4%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Health Care Center, Osaka University 1-17 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan

    Makoto Nishida

  2. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan

    Tohru Funahashi & Iichiro Shimomura

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  1. Makoto Nishida
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Nishida, M., Funahashi, T. & Shimomura, I. Pathophysiological significance of adiponectin. Med Mol Morphol 40, 55–67 (2007). https://doi.org/10.1007/s00795-007-0366-7

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  • DOI: https://doi.org/10.1007/s00795-007-0366-7

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