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Diabetes-related symptoms and negative mood in participants of a targeted population-screening program for type 2 diabetes: The Hoorn Screening study

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Objective: To determine the level of diabetes-related symptom distress and its association with negative mood in subjects participating in a targeted population-screening program, comparing those identified as having type 2 diabetes vs. those who did not. Research design and methods: This study was conducted within the framework of a targeted screening project for type 2 diabetes in a general Dutch population (age 50–75 years). The study sample consisted of 246 subjects, pre-selected on the basis of a high-risk profile; 116 of whom were subsequently identified as having type 2 diabetes, and 130 who were non-diabetic subjects. Diabetes-related symptom distress and negative mood was assessed ∼2 weeks, 6 months, and 12 months after the diagnosis of type 2 diabetes, with the Type 2 Diabetes Symptom Checklist and the Negative well-being sub scale of the Well-being Questionnaire (W-BQ12), respectively. Results: Screening-detected diabetic patients reported significantly greater burden of hyperglycemic (F=6.0, df=1, p=0.015) and of fatigue (F=5.3, df=1, p=0.023) symptoms in the first year following diagnosis type 2 diabetes compared to non-diabetic subjects. These outcomes did not change over time. The total symptom distress (range 0–4) was relatively low for both screening-detected diabetic patients (median at ∼2 weeks, 6 months, and 12 months; 0.24, 0.24, 0.29) and non-diabetic subjects (0.15, 0.15, 0.18), and not significantly different. No average difference and change over time in negative well-being was found between screening-detected diabetic patients and non-diabetic subjects. Negative well-being was significantly positive related with the total symptom distress score (regression coefficient β=2.86, 95% CI 2.15–3.58). Conclusions: The screening-detected diabetic patients were bothered more by symptoms of hyperglycemia and fatigue in the first year following diagnosis type 2 diabetes than non-diabetic subjects. More symptom distress is associated with increased negative mood in both screening-detected diabetic patients and non-diabetic subjects.

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References

  1. MI Harris R Klein TA Welborn MW. Knuiman (1992) ArticleTitleOnset of NIDDM occurs at least 4–7 yr before clinical diagnosis Diabetes Care. 15 815–819 Occurrence Handle1:STN:280:By2A1cjgs1E%3D Occurrence Handle1516497

    CAS  PubMed  Google Scholar 

  2. American Diabetes Association. Screening for diabetes (Position statement). Diabetes Care 2002; 25(Suppl 1): S21–S24

    Google Scholar 

  3. B Lindahl L Weinehall K Asplund G. Hallmans (1999) ArticleTitleScreening for impaired glucose tolerance. Results from a population-based study in 21,057 individuals Diabetes Care. 22 1988–1992 Occurrence Handle1:STN:280:DC%2BD3c%2FlsFWnsQ%3D%3D Occurrence Handle10587831

    CAS  PubMed  Google Scholar 

  4. GT Ko JC Chan LW Tsang VT Yeung CC Chow CS. Cockram (2000) ArticleTitleOutcomes of screening for diabetes in high-risk Hong Kong Chinese subjects Diabetes Care. 23 1290–1294 Occurrence Handle1:STN:280:DC%2BD3M%2Fls1Sgtw%3D%3D Occurrence Handle10977020

    CAS  PubMed  Google Scholar 

  5. DS Lee P Remington J Madagame J. Blustein (2000) ArticleTitleA cost analysis of community screening for diabetes in the central Wisconsin Medicare population (results from the MetaStar pilot project in Wausau) WMJ. 99 39–43 Occurrence Handle1:STN:280:DC%2BD3cvhtVKjtg%3D%3D

    CAS  Google Scholar 

  6. E Goyder L. Irwig (1998) ArticleTitleScreening for diabetes: What are we really doing? BMJ. 317 1644–1646 Occurrence Handle1:STN:280:DyaK1M%2FmsFCmug%3D%3D Occurrence Handle9848909

    CAS  PubMed  Google Scholar 

  7. MI Harris RC. Eastman (2000) ArticleTitleEarly detection of undiagnosed diabetes mellitus: A US perspective Diabetes Metab Res Rev. 16 230–236 Occurrence Handle10.1002/1520-7560(2000)9999:9999<::AID-DMRR122>3.3.CO;2-N Occurrence Handle1:STN:280:DC%2BD3cvis1Gksg%3D%3D Occurrence Handle10934451

    Article  CAS  PubMed  Google Scholar 

  8. MM Engelgau KM. Narayan (2001) ArticleTitleFinding undiagnosed type 2 diabetes: Is it worth the effort? Eff Clin Pract. 4 281–283 Occurrence Handle1:STN:280:DC%2BD38%2Fkt12htw%3D%3D Occurrence Handle11769302

    CAS  PubMed  Google Scholar 

  9. K Borch-Johnsen T Lauritzen C Glumer A. Sandbaek (2003) ArticleTitleScreening for Type 2 diabetes – Should it be now? Diabet Med. 20 175–181 Occurrence Handle10.1046/j.1464-5491.2003.00842.x Occurrence Handle1:STN:280:DC%2BD3s7mtVOkug%3D%3D Occurrence Handle12675659

    Article  CAS  PubMed  Google Scholar 

  10. WH. Polonsky (2002) ArticleTitleEmotional and quality-of-life aspects of diabetes management Curr Diabet Rep. 2 153–159

    Google Scholar 

  11. MA Testa DC. Simonson (1998) ArticleTitleHealth economic benefits and quality of life during improved glycemic control in patients with type 2 diabetes mellitus: A randomized, controlled, double-blind trial JAMA 280 1490–1496 Occurrence Handle10.1001/jama.280.17.1490 Occurrence Handle1:STN:280:DyaK1M%2FisFKjsw%3D%3D Occurrence Handle9809729

    Article  CAS  PubMed  Google Scholar 

  12. FE Van der Does JN De Neeling FJ Snoek PJ Kostense PA Grootenhuis LM Bouter et al. (1996) ArticleTitleSymptoms and well-being in relation to glycemic control in type II diabetes Diabetes Care. 19 204–210 Occurrence Handle1:STN:280:BymA2c7psVM%3D Occurrence Handle8742562

    CAS  PubMed  Google Scholar 

  13. NR Kressin A Spiro Suffix3rd KM. Skinner (2000) ArticleTitleNegative affectivity and health-related quality of life Med Care. 38 858–867 Occurrence Handle10.1097/00005650-200008000-00009 Occurrence Handle1:STN:280:DC%2BD3czpslylsQ%3D%3D Occurrence Handle10929997

    Article  CAS  PubMed  Google Scholar 

  14. LA Palinkas E Barrett-Connor DL. Wingard (1991) ArticleTitleType 2 diabetes and depressive symptoms in older adults: A population-based study Diabet Med. 8 532–539 Occurrence Handle1:STN:280:By6A28vjtlA%3D Occurrence Handle1832352

    CAS  PubMed  Google Scholar 

  15. RJ Anderson KE Freedland RE Clouse PJ. Lustman (2001) ArticleTitleThe prevalence of comorbid depression in adults with diabetes: A meta-analysis Diabetes Care. 24 1069–1078 Occurrence Handle1:STN:280:DC%2BD3M3pt1GitA%3D%3D Occurrence Handle11375373

    CAS  PubMed  Google Scholar 

  16. SH Saydah FL Brancati SH Golden J Fradkin MI. Harris (2003) ArticleTitleDepressive symptoms and the risk of type 2 diabetes mellitus in a US sample Diabetes Metab Res Rev. 19 202–208 Occurrence Handle12789653

    PubMed  Google Scholar 

  17. C Arroyo FB Hu LM Ryan I Kawachi GA Colditz FE Speizer et al. (2004) ArticleTitleDepressive symptoms and risk of type 2 diabetes in women Diabetes Care. 27 129–133 Occurrence Handle14693978

    PubMed  Google Scholar 

  18. SH Golden JE Williams DE Ford HC Yeh C Paton Sanford FJ Nieto et al. (2004) ArticleTitleDepressive symptoms and the risk of type 2 diabetes: The atherosclerosis risk in communities study Diabetes Care. 27 429–435 Occurrence Handle14747224

    PubMed  Google Scholar 

  19. F Pouwer AT Beekman G Nijpels JM Dekker FJ Snoek PJ Kostense et al. (2003) ArticleTitleRates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: Results from a community-based study Diabetologia. 46 892–898 Occurrence Handle1:STN:280:DC%2BD3szmtlShsw%3D%3D Occurrence Handle12819896

    CAS  PubMed  Google Scholar 

  20. PJ Lustman RJ Anderson KE Freedland M Groot Particlede RM Carney RE. Clouse (2000) ArticleTitleDepression and poor glycemic control: A meta-analytic review of the literature Diabetes Care. 23 934–942 Occurrence Handle1:STN:280:DC%2BD3M%2FhtlGgtA%3D%3D Occurrence Handle10895843

    CAS  PubMed  Google Scholar 

  21. PS Ciechanowski WJ Katon JE Russo IB. Hirsch (2003) ArticleTitleThe relationship of depressive symptoms to symptom reporting, self-care and glucose control in diabetes Gen Hosp Psychiatry. 25 246–252 Occurrence Handle12850656

    PubMed  Google Scholar 

  22. WW Eaton H Armenian J Gallo L Pratt DE. Ford (1996) ArticleTitleDepression and risk for onset of type II diabetes A prospective population-based study. Diabetes Care. 19 1097–1102 Occurrence Handle1:STN:280:ByiD2c7ivVA%3D Occurrence Handle8886555

    CAS  PubMed  Google Scholar 

  23. N Kawakami N Takatsuka H Shimizu H. Ishibashi (1999) ArticleTitleDepressive symptoms and occurrence of type 2 diabetes among Japanese men Diabetes Care. 22 1071–1076 Occurrence Handle1:STN:280:DyaK1Mzhslajsw%3D%3D Occurrence Handle10388970

    CAS  PubMed  Google Scholar 

  24. MR Carnethon LS Kinder JM Fair RS Stafford SP. Fortmann (2003) ArticleTitleSymptoms of depression as a risk factor for incident diabetes: Findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971–1992 Am J Epidemiol. 158 416–423 Occurrence Handle12936896

    PubMed  Google Scholar 

  25. AM Spijkerman MC Adriaanse JM Dekker G Nijpels CD Stehouwer LM Bouter et al. (2002) ArticleTitleDiabetic patients detected by population-based stepwise screening already have a diabetic cardiovascular risk profile Diabetes Care. 25 1784–1789 Occurrence Handle12351478

    PubMed  Google Scholar 

  26. JB Ruige JN Neeling Particlede PJ Kostense LM Bouter RJ. Heine (1997) ArticleTitlePerformance of an NIDDM screening questionnaire based on symptoms and risk factors Diabetes Care. 20 491–496 Occurrence Handle1:STN:280:ByiB2M7ivVE%3D Occurrence Handle9096967

    CAS  PubMed  Google Scholar 

  27. PA Grootenhuis FJ Snoek RJ Heine LM. Bouter (1994) ArticleTitleDevelopment of a type 2 diabetes symptom checklist: A measure of symptom severity Diabet Med. 11 253–261 Occurrence Handle1:STN:280:ByuA3cnos1Y%3D Occurrence Handle8033523

    CAS  PubMed  Google Scholar 

  28. C. Bradley (1994) The Well-Being Questionnaire Handbook. of Psychology and Diabetes: A Guide to Psychological Measurement in Diabetes Research and Practice Harwood Academic Chur, Switzerland. 89–109

    Google Scholar 

  29. F Pouwer HM Ploeg Particlevan der HJ Ader RJ Heine FJ. Snoek (1999) ArticleTitleThe 12-item well-being questionnaire. An evaluation of its validity and reliability in Dutch people with diabetes. Diabetes Care. 22 2004–2010 Occurrence Handle1:STN:280:DC%2BD3c%2FlsFWntA%3D%3D Occurrence Handle10587834

    CAS  PubMed  Google Scholar 

  30. WWK. Zung (1965) ArticleTitleA self-rating depression scale Arch Gen Psychiatry. 12 63–70 Occurrence Handle1:STN:280:CCqD38ngvFc%3D Occurrence Handle14221692

    CAS  PubMed  Google Scholar 

  31. WWK. Zung (1974) The Measurement of Affects: Depression and Anxiety Karger Basel. 170–188

    Google Scholar 

  32. A. DG. (1965) Comparing Groups – Continuous Data Chapman & Hall London. 179–228

    Google Scholar 

  33. JM. Schrof (1999) ArticleTitleThe silent killer. By the time diabetes is diagnosed, it may be too late US News World Rep. 126 50–52

    Google Scholar 

  34. J. Roth (2000) ArticleTitleWidening awareness of hyperglycemia unawareness Diabetes Metab Res Rev. 16 228–229 Occurrence Handle1:STN:280:DC%2BD3cvis1Gluw%3D%3D Occurrence Handle10934450

    CAS  PubMed  Google Scholar 

  35. M. Muggeo (1998) ArticleTitleAccelerated complications in Type 2 diabetes mellitus: The need for greater awareness and earlier detection Diabet Med. 15 IssueID(Suppl 4 S60–S62 Occurrence Handle9868995

    PubMed  Google Scholar 

  36. BM Singh DM Jackson R Wills J Davies PH. Wise (1992) ArticleTitleDelayed diagnosis in non-insulin dependent diabetes mellitus BMJ. 304 1154–1155 Occurrence Handle1:STN:280:ByyD3cngvVE%3D Occurrence Handle1392794

    CAS  PubMed  Google Scholar 

  37. DM Jackson R Wills J Davies K Meadows BM Singh PH. Wise (1991) ArticleTitlePublic awareness of the symptoms of diabetes mellitus Diabet Med. 8 971–972 Occurrence Handle1:STN:280:By2C3snns1w%3D Occurrence Handle1838052

    CAS  PubMed  Google Scholar 

  38. AJ Thomas RN Kalaria JT. O’Brien (2004) ArticleTitleDepression and vascular disease: What is the relationship? J Affect Disord. 79 81–95 Occurrence Handle15023483

    PubMed  Google Scholar 

  39. MC Gulliford D. Mahabir (1999) ArticleTitleRelationship of health-related quality of life to symptom severity in diabetes mellitus: A study in Trinidad and Tobago J Clin Epidemiol. 52 773–780 Occurrence Handle1:STN:280:DyaK1Mzpt12qsw%3D%3D Occurrence Handle10465322

    CAS  PubMed  Google Scholar 

  40. KJ Petrie J. Weinman (2003) ArticleTitleMore focus needed on symptom appraisal J Psychosom Res. 54 401–403 Occurrence Handle12726893

    PubMed  Google Scholar 

  41. MC Adriaanse FJ Snoek JM Dekker AM Spijkerman G Nijpels HM Ploeg Particlevan der et al. (2003) ArticleTitlePerceived risk for Type 2 diabetes in participants in a stepwise population-screening programme Diabet Med. 20 210–215 Occurrence Handle1:STN:280:DC%2BD3s7lvFGktw%3D%3D Occurrence Handle12675665

    CAS  PubMed  Google Scholar 

  42. BM Singh JJ Prescott R Guy S Walford M Murphy PH. Wise (1994) ArticleTitleEffect of advertising on awareness of symptoms of diabetes among the general public: The British Diabetic Association Study BMJ. 308 632–636 Occurrence Handle1:STN:280:ByuC1MfntVA%3D Occurrence Handle8148713

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute for Research in Extramural Medicine (EMGO-Institute), Institute for Health Sciences, Faculty of Earth and Life Sciences, VU University Medical Centre, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081, Amsterdam, HV, The Netherlands

    Marcel C. Adriaanse, Jacqueline M. Dekker, Annemieke M. W. Spijkerman, Jos W. R. Twisk, Giel Nijpels, Henk M. van der Ploeg, Robert J. Heine & Frank J. Snoek

  2. Department of Medical Psychology, VU University Medical Centre, Amsterdam, The Netherlands

    Henk M. van der Ploeg & Frank J. Snoek

  3. Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands

    Robert J. Heine

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  1. Marcel C. Adriaanse
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  2. Jacqueline M. Dekker
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Correspondence to Marcel C. Adriaanse.

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Adriaanse, M.C., Dekker, J.M., Spijkerman, A.M.W. et al. Diabetes-related symptoms and negative mood in participants of a targeted population-screening program for type 2 diabetes: The Hoorn Screening study. Qual Life Res 14, 1501–1509 (2005). https://doi.org/10.1007/s11136-004-0028-3

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