Original articleJugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass☆
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2022, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :In contrast, there is an evolving body of evidence, first observational, and then from three randomized, prospective studies, that has shown an association between intraoperative cerebral desaturation and POCD.42-44,66,67 Observational evidence supports an AUC for desaturation <40% as the key predictor for POCD.66,82-85 Furthermore, prospective RCT data from patients (n = 265) undergoing on-pump CABG showed no significant incidence of POCD without desaturation <50%, and reinforced that desaturation load was associated with significant increased incidence of early POCD.67
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This research was supported in part by grant RO1-AG09663 from the National Institutes of Health.
Copyright © 1994 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.