Research paperProtection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase
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2022, Archives of Biochemistry and BiophysicsCitation Excerpt :Isolated LDL is readily oxidized in vitro using copper, but coincubation with HDL or with PON1 largely inhibits to formation of LOOH or the breakdown of LOOH to reactive lipid aldehydes such as MDA under these conditions [28,29]. Although PON1 is a relatively minor protein component of HDL, it appears to be essential for the antioxidative effects of HDL [10,28,30,31]. PON1 competes with MPO for binding to apoA1 [32], which may protect HDL phospholipids from peroxidation, as MPO is a major source of reactive oxygen species that cause lipid peroxidation in circulation [33].
Copyright © 1993 Published by Elsevier Ltd.