Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat☆,☆☆
References (36)
- et al.
The morphogenesis of testicular degeneration induced by orally administered 2,5-hexanedione
Exp. Mol. Pathol
(1983) - et al.
Covalent binding of a neurotoxic n-hexane metabolite: Conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione
Toxicol. Appl. Pharmacol
(1982) - et al.
Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure
Toxicol. Appl. Pharmacol
(1985) - et al.
Neurotoxicity and protein binding of 2,5-hexanedione in the hen
Toxicol. Appl. Pharmacol
(1983) - et al.
Metabolic fate and disposition of 14C-labeled methyl n-butyl ketone in the rat
Toxicol. Appl. Pharmacol
(1977) - et al.
Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance
Toxicol. Appl. Pharmacol
(1976) - et al.
Evidence that pyrrole formation is a pathogenetic step in γ-diketone neuropathy
Toxicol. Appl. Pharmacol
(1987) - et al.
Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking
Toxicol. Appl. Pharmacol
(1982) - et al.
An H-1, C-13, and N-15 NMR study of the Paal-Knorr condensation of acetonylacetone with primary amines
Tetrahedron
(1986) - et al.
Pathogenesis of experimental giant neurofilamentous axonopathies: A unified hypothesis based on chemical modification of neurofilaments
Brain Res. Rev
(1985)
Structural basis of γ-diketone neurotoxicity: Non-neurotoxicity of 3,3-dimethyl-2,5-hexanedione, a γ-diketone incapable of pyrrole formation
Toxicol. Appl. Pharmacol
(1986)
On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy
Toxicol. Appl. Pharmacol
(1978)
Rapid reorganization of the axonal cytoskeleton induced by a gamma diketone
Brain Res
(1983)
Electrophilic substitution in pyrroles. Part 4. Hydrogen exchange in acid solution
J. Chem. Soc. Perkin Trans
(1980)
The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking
Toxicol. Appl. Pharmacol
(1983)
Directive effects in the attack of phenyl radicals on carbon-hydrogen bonds
J. Amer. Chem. Soc
(1963)
2,5-Hexanedione neuropathy is associated with the covalent crosslinking of neurofilament proteins
Neurochem. Pathol
(1986)
Bulk preparation of CNS cytoskeleton and the separation of individual neurofilament proteins by gel filtration: Dye-binding characteristics and amino acid compositions
J. Neurochem
(1982)
Cited by (0)
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This work was supported by PHS/NIOSH Grant OH-01972.
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A preliminary report of this research was presented at the 26th Annual Meeting of the Society of Toxicology, Washington, DC, Feb. 23–27, 1987.
Copyright © 1988 Published by Elsevier Inc.