Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation
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Cited by (83)
Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :In rats injected with streptozotocin (STZ), NGF has a fast and dramatic increase in lumbosacral dorsal root ganglion while it decreases gradually later [58] and reaches at a significantly lower level in both dorsal root ganglion and bladder after a prolonged period [58–60], resulting a reverse “U” shape change of NGF. Diabetes-associated decrease in NGF, however, can be restored by islet transplantation [61]. In humans, T1DM patients without complications such as neuropathy, retinopathy or nephropathy have higher serum NGF levels than non-diabetic people [62].
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
2018, European Journal of PharmacologyCitation Excerpt :In STZ-induced diabetic rats, the amount of anterogradely transported SP was reduced (Garrett et al., 1995; Robinson et al., 1987). Hellweg and colleagues found that the concentration of endogenous NGF in STZ-diabetic rats was reduced and could be corrected by islet transplantation (Hellweg et al., 1991). Following the study, the author also found reduced retrograde transport of NGF in diabetic rats.
Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms
2018, Life SciencesCitation Excerpt :Hence, downregulation of NGF is considered to be one of the most important factors contributing to the pathogenesis of diabetic neuropathy beside the chronic hyperglycemia and hypoxia [79,80]. In brief, hyperglycemia promotes neuroinflammation caused by ROS generation, which in turn causes microglial and astrocytic activation with subsequent nerve damage, apoptosis and defect in axonal transport causing sharp decline in the levels of NGF seen in PDN [73,74]. On the other hand, microglia inactivation produced by duloxetine is expected to suppress the inflammatory reactions involved in PDN after peripheral nerve injury and restore peripheral nerve function [69] as well as neuroregeneration with subsequent elevation of NGF.
Non-musculoskeletal benefits of vitamin D
2018, Journal of Steroid Biochemistry and Molecular BiologyWherefore Art Thou, O Treatment for Diabetic Neuropathy?
2016, International Review of NeurobiologyVitamins C and E (ascorbate/α-tocopherol) provide synergistic neuroprotection in the jejunum in experimental diabetes
2015, PathophysiologyCitation Excerpt :The receptors for NTs belong to the tyrosine kinase family (TrkA, TrkB and TrkC), with NGF having a higher specificity for TrkA [43]. Previous studies have shown a lower expression of NGF in diabetic animals, which supports another hypothesis for the induction of the enteric neuropathy [44]. Rush et al. [45] and Mendell et al. [46] showed that the activation of Trk receptors by NGF in the CNS was involved in neuroplasticity processes and may regulate the size of the cell body.