Original articleMedical risk factors in diabetic patients with foot ulcers and severe peripheral vascular disease and their influence on outcome
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Cited by (59)
Toe Pressure in Predicting Diabetic Foot Ulcer Healing: A Systematic Review and Meta-analysis
2019, Annals of Vascular SurgeryEarly revascularization after admittance to a diabetic foot center affects the healing probability of ischemic foot ulcer in patients with diabetes
2014, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :Peripheral edema has previously been shown to be related to foot ulcer healing in patients with diabetes.6,24 Peripheral edema was also found to be more common in patients with diabetes and foot ulcer who required amputation or died unhealed than in those with primary healing.6,24–26 Edema is often multifactorial in origin, and its treatment should also focus on the predisposing cause.
Assessment of risk factors in diabetic foot ulceration and their impact on the outcome of the disease
2009, Primary Care DiabetesCitation Excerpt :The main examined sensory modalities were pain, touch and vibration sense over the medial malleollus of the affected foot. The patient was considered to have peripheral vascular disease that may affect the development of ulcer if there was absent pulsation of either the dorsalis pedis or posterior tibial artery, or ankle–brachial systolic blood pressure index <0.80 [32]. Chronic renal insufficiency was stratified as creatinine >4.0 mg/dl, current dialysis or a history of renal transplantation [33] while the presence of diabetic retinopathy was assessed by one independent ophthalmologist.
Four-fold increase in foot ulcers in type 2 diabetic subjects without an increase in major amputations by a multidisciplinary setting
2009, Diabetes Research and Clinical PracticeCitation Excerpt :As secondary prophylaxis, a rapid and effective contact system in the foot clinic when ulcer recurrences occur seems mandatory. Foot ulcers are an important risk factor for and preclude nearly all amputations above or under the knee [28,5,6]. Strong associations were found between amputations and other diabetic complications, such as peripheral neuropathy and peripheral ischemia, which is in concordance with previous studies [7,8].
Fifty percent area reduction after 4 weeks of treatment is a reliable indicator for healing-analysis of a single-center cohort of 704 diabetic patients
2009, Journal of Diabetes and its ComplicationsCitation Excerpt :In our analysis, the probability of healing was significantly decreased for ulcers that did not reach 50% area reduction after 4 weeks of treatment. It has been shown that ischemic wounds (Apelqvist, Larsson, & Agardh, 1992) have a significantly lower healing rate and a higher risk for amputation. Similarly, wound infection has an impact and is very likely to delay the healing process (Lipsky et al., 2006).
Factors associated with treatment failure in patients with diabetic foot infections: An analysis of data from randomized controlled trials
2008, Diabetes Research and Clinical PracticeCitation Excerpt :The production of biofilms, in which antibiotic penetration may be prohibited, may also contribute to treatment failures. Although several studies were performed to identify factors that could be associated with the development of diabetic foot ulcers or infections [39–44], we are aware of only one study that sought to identify factors that could be associated with adverse outcome. The authors of this study concluded that fever, increased serum creatinine levels at baseline, prior hospitalization for diabetic foot lesions and gangrenous lesions were the independent factors associated with treatment failure [45].