Long-term developmental follow-up of infants of diabetic mothers☆,☆☆,★,★★
Section snippets
METHODS
Our study was conducted to complement the University of Washington's component of the multicenter collaborative Diabetes in Early Pregnancy project, a study funded and coordinated by the National Institute of Child Health and Human Development. The DIEP project was designed to quantify the risk of malformations in offspring of insulin-dependent diabetic mothers and to identify the factor or factors associated with the increased risk associated with pregnancies of diabetic women. The original
Maternal characteristics
Although the mothers had not necessarily planned to participate in a follow-up study at the time of enrollment in the original DIEP study, 71% of the families who agreed to participate in the follow-up continued their involvement through the completion of our 3-year study. Among diabetic mothers, but not control mothers, those with more education were less likely to leave the study prematurely.
Our study and control populations were primarily white, married, of middle income, and well educated.
DISCUSSION
The purpose of this study was to determine whether maternal insulin-dependent diabetes results in impaired neurodevelopment in childhood. Previous studies2, 7 have suggested that infants born to insulin-dependent diabetic mothers are at risk of having neurodevelopmental sequelae. In conducting this study, the majority of infants were followed for a 3-year period and the characteristics of the pregnant diabetic women and their newborn infants were similar to those from the larger, five-center
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Cited by (0)
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From the Departments of Pediatrics, Psychiatry and Behavioral Sciences, Obstetrics and Gynecology, and Medicine, the Child Development and Mental Retardation Center, University of Washington, Seattle, and the Child Development and Rehabilitation Center, Oregon Health Sciences University, Portland
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Supported by National Institute of Child Health and Human Development grant No. 1R01 HD17212-01A1, by March of Dimes Birth Defects Foundation grant No. 12-81, and by the Clinical Nutrition Research Unit (CNRU) (University of Washington, Seattle) grant No. DK-35816.
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Reprint requests: Clifford J. Sells, MD, MPH, Child Development and Rehabilitation Center, PO Box 574, Portland, OR 97207-0574.
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0022-3476/94/$3.00 + 0 9/73/55227