Decreased glucose effectiveness but not insulin resistance in glucose-tolerant offspring of Japanese non—insulin-dependent diabetic patients: A minimal-model analysis
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Cited by (27)
Pathogenic Mechanisms of Prediabetes in Obese vs. Very Obese African American Women: Implications for Diabetes Prevention
2019, Journal of the National Medical AssociationCitation Excerpt :Sg serves as an additional compensatory mechanism for total body glucose disposal. In this regard, we10,12,17,20,21,24,28 and others11,14,22,23,27–32 have shown that Sg and/or GEZI are normal or higher in insulin resistant, nondiabetic AAs than white Americans. Surprisingly, in the present study, we found that, Sg/GEZI did not differ in OB vs VOB AA women with prediabetes.
Ethnic differences in glucose effectiveness and disposition index in overweight/obese African American and white women with prediabetes: A study of compensatory mechanisms
2017, Diabetes Research and Clinical PracticeCitation Excerpt :In this context, we have previously shown that Sg is decreased in AA and other black populations with IGT and type 2 diabetes [3,5,6,16–19]. In addition, Doi et al. [11] reported lower Sg rather than Si in adult offspring of Japanese patients with type 2 diabetes. However, we [3,6,16,20,21] and Ellis et al. [22] have shown that Sg is normal or greater in insulin resistant AA with normal glucose tolerance when compared to their WA counterparts.
Evidence for pancreatic β-cell dysfunction in brothers of women with polycystic ovary syndrome
2008, Metabolism: Clinical and ExperimentalCitation Excerpt :The acute insulin response to glucose (AIRg) was calculated as the increment area under curve from basal of insulin values measured at 2 to 10 minutes and disposition index (DI; β-cell compensation index) as the product of SI and AIRg [21-23]. Glucose clearance (KG), a parameter of glucose tolerance, was calculated from the FSIGT as the slope of the least square regression line to the natural log of the glucose concentration vs time from 10 to 19 minutes after the glucose injection [5,24]. Plasma glucose levels were determined by glucose oxidase method.
Pathophysiologic phenotypes of Japanese subjects with varying degrees of glucose tolerance: Using the combination of C-peptide secretion rate and minimal model analysis
2001, Metabolism: Clinical and ExperimentalIncreased insulin sensitivity and decreased insulin secretion in offspring of insulin-sensitive type 2 diabetic patients
2000, Metabolism: Clinical and Experimental