Endocrinology and Metabolism Clinics of North America
Review articleObesity and dyslipidemia
Section snippets
Lipoproteins and body weight
Obesity is always associated with increases in plasma triglycerides. Analysis of the Second National Health and Nutrition Educational Survey (NHANES II) data, which represent a random sample of US adults within a wide range of age and socioeconomic status, shows an increase in triglyceride levels with increasing obesity in white men and women of all ages. A difference of approximately 100 mg/dL was found to occur between normal-weight and obese men [2], with a difference of approximately 60
Pathophysiology of dyslipidemia in obesity
As discussed previously, abnormalities in lipoproteins are more pronounced in individuals with central obesity, with the implication that insulin resistance plays a role in the lipoprotein changes seen with increasing body fat. A systematic review of the potential metabolic abnormalities that underlie lipoprotein changes is presented in the following sections (Fig. 7). Because studies of people with obesity and of people with insulin resistance have shown essentially the same results, the
Summary
The primary dyslipidemia related to obesity is characterized by increased triglycerides, decreased HDL levels, and abnormal LDL composition. Much work has been done to elucidate the pathogenesis of the dyslipidemia of obesity, which seems to be closely related to insulin resistance in obese individuals; however, more studies in humans are needed to further understand the metabolic mechanisms underlying the changes, and to distinguish between the roles of insulin resistance and body fat in the
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