The International Journal of Biochemistry & Cell Biology
Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice
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2021, Seminars in Cell and Developmental BiologyCitation Excerpt :Conversely, pro-inflammatory macrophages make up 80% of the total cell number at the wound margins of mouse diabetic wounds and chronic venous ulcers seen in humans [98], resulting in excessive reactive oxygen species (ROS) [99], and pro-inflammatory cytokine production such as Il-1β, IL-17 and TNFα within these wounds [97,100]. Chronic wound patients in the clinic also present with high levels of pro-inflammatory cytokines such as TNFα in their wound exudate [101], which is linked to changes in expression of MMPs that increase ECM proteolysis, as well as increases in apoptotic load, both of which feedback to elevate inflammation and hence contribute to wound chronicity [102,103]. However, despite the increased number of macrophages in chronic wounds, angiogenesis is shown to be insufficient, with decreased capillary density and vascularity in diabetic wounds [104].
Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice
2020, Journal of EthnopharmacologyAutologously transplanted dermal fibroblasts improved diabetic wound in rat model
2020, Acta HistochemicaCitation Excerpt :In addition to fibroblasts in the wound area, there are studies showing that they originate from pericytes, smooth muscle cells, or bone marrow-derived circulating fibrocytes which are CD34+, CD45+ and collagen Type 1+ cells (Quan et al., 2004; Mori et al., 2005; Herzog and Bucala, 2010). Several studies have shown that myofibroblast differentiation is delayed and inadequate wound contraction occurs in diabetes (Darby et al., 1997; Achar et al., 2014; Cheing et al., 2014). In our study, 5-day wound healing in the experimental diabetes group showed that α-SMA expression was significantly decreased compared to the control group and that diabetes had a negative effect on myofibroblast cell differentiation.
Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing
2020, International Journal of Biological MacromoleculesPreclinical study of diabetic foot ulcers: From pathogenesis to vivo/vitro models and clinical therapeutic transformation
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