Original articleA Pilot Study of Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes
Section snippets
Methods
A retrospective analysis was performed of healthy eyes of patients who underwent EDI OCT imaging. The method of obtaining EDI OCT images has been reported previously.4 The choroid was imaged by positioning a Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) close enough to the eye to obtain an inverted image. This image is averaged for 100 scans using the automatic averaging and eye tracking features. Seven sections, each comprised of the 100 averaged scans, were obtained in a
Results
Thirty patients (54 eyes) were included in this study (Figure 1). The mean age of the patients was 50.4 years (range, 19 to 85 years), 14 patients (46.7%) were female, and the mean refractive error was −1.3 D (standard deviation [SD], ± 2.1 D). The mean choroidal thickness as a function of distance from the fovea is shown in Figure 2. The choroidal thickness measurements at each location were significantly correlated with measurements at all other locations in each eye (Table 1). The mean
Discussion
In this study, EDI OCT measurement showed variations in cross-sectional choroidal thickness in healthy eyes of patients with varying ages. In a horizontal section centered on the fovea, the choroidal thickness was greatest at the fovea and decreased more nasally than temporally. The choroidal thicknesses at all measured points in this section were correlated inversely with age.
There are no comparable studies with which we can compare our results. Histologic evaluation of the choroid carries
References (22)
- et al.
Choroidal blood flow as a heat dissipating mechanism in the macula
Am J Ophthalmol
(1980) - et al.
Enhanced depth imaging spectral-domain optical coherence tomography
Am J Ophthalmol
(2008) - et al.
High-resolution ultrasonic imaging of the posterior segment
Ophthalmology
(2004) Choroidal innervation in primate eyes
Exp Eye Res
(2006)- et al.
Reflex choroidal blood flow responses of the eyeball following somatic sensory stimulation in rats
Auton Neurosci
(2002) - et al.
Age-related macular changes in humans over 90 years old
Am J Ophthalmol
(1990) - et al.
Fluorescein studies of normal choroidal circulation
Am J Ophthalmol
(1970) - et al.
Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss
Ophthalmology
(2000) Age-related choroidal atrophy
Am J Ophthalmol
(2009)- et al.
Metabolic dependence of photoreceptors on the choroid in the normal and detached retina
Invest Ophthalmol Vis Sci
(2000)
Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc
Br J Ophthalmol
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