Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1812, Issue 8, August 2011, Pages 893-908
ReviewRole of nuclear receptor SHP in metabolism and cancer☆
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Research highlights
► SHP generally functions as a transcriptional repressor. ► SHP interacts with a wide variety of nuclear receptors and transcription factors. ► SHP regulates the development of fatty liver, obesity, diabetes and cancer. ► SHP is a critical regulator of miRNA gene transcription.
Keywords
Nuclear receptors
Small heterodimer partner
Metabolic regulation
Metabolic syndrome
Cancer
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This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
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