Cell Metabolism
Volume 17, Issue 6, 4 June 2013, Pages 851-859
Journal home page for Cell Metabolism

Perspective
Immunological Goings-on in Visceral Adipose Tissue

https://doi.org/10.1016/j.cmet.2013.05.008Get rights and content
Under an Elsevier user license
open archive

Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.

Cited by (0)