Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients

https://doi.org/10.1016/j.diabres.2011.03.021Get rights and content
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Abstract

Aim

Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions.

Methods

60 male type 2 diabetes patients (HbA1c 7.5 ± 0.1% [58 ± 1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring.

Results

Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38 ± 4% of the day. Even diabetes patients with an HbA1c level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24 ± 5% throughout the day. Hyperglycemia was negligible in the control group (3 ± 1%).

Conclusion

Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA1c level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.

Keywords

Type 2 diabetes mellitus
Postprandial hyperglycemia
Normal glucose tolerance
Glycemic control
Continuous glucose monitoring

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Both authors contributed equally to the manuscript.