Original StudyPatients With Type 2 Diabetes Show a Greater Decline in Muscle Mass, Muscle Strength, and Functional Capacity With Aging
Section snippets
Subjects
Ninety-two older men were included in the present study: 60 with type 2 diabetes (71 ± 1 years) and 32 age-matched normoglycemic controls (70 ± 1 years). All subjects were community dwelling and still living independently. All subjects were recruited through advertisements in local newspapers. Medical history of all subjects was evaluated and an oral glucose tolerance test and resting and exercise electrocardiogram were performed before inclusion. Exclusion criteria included a recent history or
Subjects
Subjects’ characteristics are provided in Table 1. In total, 60 elderly men with type 2 diabetes and 32 normoglycemic age-matched controls were included in the study. Both groups showed no differences for age, body weight, height, BMI, HOMA, and ISI. The group with type 2 diabetes presented significantly higher basal plasma glucose and HbA1c values and lower basal plasma insulin concentrations when compared with the normoglycemic group.
Dietary Intake and Physical Activity
A significant difference was observed in total energy
Discussion
The present study shows that both leg lean mass and ASM are lower in older patients with type 2 diabetes when compared with age-matched normoglycemic controls. Additionally, leg muscle strength and functional capacity are reduced in older individuals suffering from type 2 diabetes. Reduced muscle strength and impairments in functional capacity are strongly correlated with type II muscle fiber atrophy in both normoglycemic elderly individuals and those with type 2 diabetes.
Aging is accompanied
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None of the authors have any conflicts of interest.