Original ArticleEarly onset of subclinical atherosclerosis in young persons with type 1 diabetes
Section snippets
Study population
Subjects (63 male, 79 female) 12 to 25 years of age, with type 1 diabetes defined by American Diabetes Association criteria, were recruited as a sample of convenience from the clinic population at the Children's Hospital Los Angeles Comprehensive Diabetes Center (CCDC). Eighty-seven subjects (35 male, 52 female) 12 to 25 years of age, without diabetes, were recruited for evaluation of carotid IMT only. Subjects were excluded if they had evidence or history of clinically relevant systemic
Results
Subjects without diabetes were significantly older than those with diabetes (mean [SD] = 18.8 [3.1] vs 16.0 [2.6] years, P < .001). The sample of subjects without diabetes included 35 (40%) male subjects, and the sample of subjects with diabetes included 63 (44%) male subjects (P = .54). The overall ethnic distribution was 37% white, 56% Hispanic, 4% black, and 3% other (P = .45 between groups).
Subjects with diabetes had significantly elevated age-adjusted carotid artery IMT compared with subjects
Discussion
Although they were somewhat younger than our nondiabetic sample, young persons with type 1 diabetes had increased carotid IMT relative to young persons without diabetes. Our findings support previous work regarding the early onset of atherosclerosis in adolescents and young adults with diabetes8., 9., 26., 27. and is in contrast to others who have not found a difference in carotid IMT in younger patients (3 to 18 years of age) with type 1 diabetes.28 Despite the added burden of diabetes on
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Supported by a grant from the American Diabetes Association.