Carbohydrate requirement and insulin concentration during moderate exercise in type 1 diabetic patients☆
Section snippets
Subjects
Twelve type 1 diabetic patients (6 men and 6 women) age 18 to 45 years volunteered to be subjects. A control group of 12 well-matched healthy subjects (6 males and 6 females) was also studied. All subjects were informed of the nature, purpose, and possible risks involved in the study before giving their voluntary consent to participate. The study was approved by the local ethical committee and was conducted according to the principles expressed in the Declaration of Helsinki.
Patients were
Results
According to the forms filled in by the subjects, all diabetic volunteers were compliant to the request of abstaining from exercise the day before the trials and maintaining the same diet and insulin routine the day before and after the experimental sessions.
Discussion
The experimental protocol followed for the present work allowed us to determine the amount of CHO needed by type 1 diabetic patients to prevent hypoglycemia during exercise.
Acknowledgements
We thank Dr E. Belluco, Dr L. Aita, and Dr F. Reccardini for their help during the experimental sessions and Professor P.E. di Prampero and Professor S. Del Prato for helpful discussion.
References (29)
Use of bioelectrical impedance analysis measurements in patients with diabetes
Am J Clin Nutr
(1996)- et al.
Exercise tolerance is lower in type I diabetics compared with normal young men
Metabolism
(1993) - et al.
Fuel homeostasis in exercise
N Engl J Med
(1975) - et al.
Substrate turnover during prolonged exercise in man
J Clin Invest
(1974) - et al.
Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work
Am J Physiol
(1989) - et al.
Impact of insulin deficiency on glucose fluxes and muscle glucose metabolism during exercise
Diabetes
(1992) Postexercise late-onset hypoglycemia in insulin-dependent diabetic patients
Diabetes Care
(1987)- et al.
Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue
Am J Physiol
(2000) - et al.
Effect of exercise training on insulin sensitivity in adolescents with type I diabetes
Diabetes Care
(1985) Diabetes mellitus and exercise
Diabetes Care
(1997)
Glycemic control with physical training in insulin-dependent diabetes mellitus
Am J Dis Child
Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise
Diabetes
Glucose utilization during exercise in normal and diabetic subjects. The role of insulin
Diabetes
Accommodating planned exercise in type I diabetic patients on intensive treatment
Diabetes Care
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Supported by funds from the Ministero dell’Università e della Ricerca Scientifica (MURST 60%, main investigator L. Cattin).