Original articleHyperglycemia, Blood Pressure, and the 9-Year Incidence of Diabetic Retinopathy: The Barbados Eye Studies
Section snippets
Background
The Barbados Eye Studies (1987–2003), funded by the National Eye Institute, are epidemiologic investigations of the prevalence, incidence, and risk factors for major eye diseases, including DR, in a predominantly African-origin population.13, 14, 15 The baseline prevalence study, the Barbados Eye Study (1987–1992), was based on a simple random sample of Barbadian-born citizens, 40–84 years old (4709 persons; 84% participation; 93% black by self-report).13 The surviving cohort was invited for
Results
This report is based on 324 cohort participants with DM at baseline, who were at risk for developing DR during the 9 years of follow-up.12 Their median age was 58 years, and 64% were female. Table 1 presents the 9-year incidence of DR in this group by various baseline features. Incidence rates did not vary by age, gender, and other characteristics presented in the table, except for age of DM onset. Based on the median age of onset, persons diagnosed with DM before 53 years of age were 1.5 times
Discussion
This long-term longitudinal study has identified several factors related to the development of DR in a population of African origin. Such information, which was not previously available, is valuable for understanding the reasons why DR develops, as well as planning strategies for prevention and targeting groups at high risk.
References (42)
- et al.
Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes
Kidney Int
(2002) - et al.
Diabetic retinopathy in a black population:the Barbados Eye Study
Ophthalmology
(1999) - et al.
Incidence of diabetic retinopathy in the Barbados Eye Studies
Ophthalmology
(2003) - et al.
Nine-year incidence of lens opacities in the Barbados Eye Studies
Ophthalmology
(2004) - et al.
Diabetic retinopathyassessment of severity and progression
Ophthalmology
(1984) - et al.
Development of diabetic retinopathy and its associated risk factors in type 2 diabetic patients in Osaka district, Japana long-term prospective study
Diabetes Res Clin Pract
(1990) - et al.
Prevalence of diabetic retinopathy in an older community. The Blue Mountains Eye Study
Ophthalmology
(1998) Photocoagulation for diabetic macular edemaEarly Treatment Diabetic Retinopathy Study report number 1
Arch Ophthalmol
(1985)Indications for photocoagulation treatment of diabetic retinopathyDiabetic Retinopathy Study Report no. 14
Int Ophthalmol Clin
(1987)The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
N Engl J Med
(1993)
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Lancet
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes UKPDS 38
BMJ
Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes
Diabetes Care
Diabetes in a Caribbean populationepidemiological profile and implications
Int J Epidemiol
Hypertension prevalence, control and survivorship in an Afro-Caribbean population
J Hypertens
The Barbados Eye Studyprevalence of open angle glaucoma
Arch Ophthalmol
Incidence of open-angle glaucomathe Barbados Eye Studies
Arch Ophthalmol
Glycosylated haemoglobin and plasma glycoprotein assays by affinity chromatography
Diabetologia
Diabetic Retinopathy Study. Report 7: a modification of the Airlie House classification of diabetic retinopathy
Invest Ophthalmol Vis Sci
Comparison of diabetic retinopathy detection by clinical examinations and photograph gradings
Arch Ophthalmol
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Supported by the National Eye Institute, Bethesda, Maryland (grant nos.: EY07625, EY07617).