Original articleSystemic Soluble Tumor Necrosis Factor Receptors 1 and 2 Are Associated with Severity of Diabetic Retinopathy in Hispanics
Section snippets
Materials and Methods
From October 2007 to December 2010, we performed a cross-sectional study of 473 Hispanic type II diabetic subjects who were recruited in a joint study of Cedars-Sinai Medical Center and the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (HUMC) after informed consent and approval by the institutional review board/ethics committee. This study assessed siblings of a proband (with type II diabetes and either known DR or a diabetes duration of ≥10 years) and, when possible,
Results
A total of 473 type II diabetic subjects with DR (cases, n = 266) and without DR (controls, n = 207) were included in the analysis (demographics of the cohort are summarized in Table 1). The mean ± standard error of the mean (SEM) age was 53.7±0.8 years in the controls and 53.6±0.7 years in the cases. There were 66 (31.9%) and 114 (42.9%) male subjects in the controls and cases, respectively. The mean body mass index (BMI) ± SEM was 33.4±0.5 and 32.1±0.4 in the controls and cases, respectively,
Discussion
After controlling for confounding risk factors, including age, gender, BMI, HbA1c, diabetes duration, systolic blood pressure, and serum creatinine or urinary albumin:creatinine ratio, both sTNF-R1 and sTNF-R2 were cross-sectionally associated with increasing severity of DR in Hispanic type II diabetic subjects. These findings reveal novel systemic biomarkers, namely, soluble TNF receptors, which may serve as a biochemical link between 2 important pathophysiologic processes involved:
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2022, Experimental Eye ResearchCitation Excerpt :Hyperglycemia and extensive glycation in diabetes induce pro-inflammatory mediators such as MCP-1, IL-6, ICAM-1, and metalloproteinase in the retina, which causes the release of TNF-α by stimulating monocytes/macrophages. Kuo et al., 2012 found that serum levels of TNF receptors were associated with both incidence and severity of DR, and patients with PDR had higher serum levels of TNF receptors than healthy individuals or patients without retinopathy (DNR). Costagliola et al.,0.2013; reported higher concentrations of TNF-α in tear samples of patients with diabetes compared to controls.
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2022, American Journal of OphthalmologyCitation Excerpt :Table 1 summarizes the DR phenotyping protocols and covariates by cohort. Phenotyping protocols have been previously described.3,9,17,32-40 All of these participants had genome-wide genotyping and were part of the GWAS.
Tumor necrosis factor-α and diabetic retinopathy: Review and meta-analysis
2018, Clinica Chimica ActaCitation Excerpt :However, the difference between the two groups was not statistically significant. This result was inconsistent with the studies by Kuo et al. [42] and Koleva-Georgieva [43]. One potential reason for the variability of TNF-α expression in the control group was the sampling error, and an alternative explanation was the effect of other undetected complications in the TNF-α level.
Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients
2018, American Journal of OphthalmologyCitation Excerpt :We noted that very few population studies were performed to explore the biomarkers that are associated with DR severity.17 Most of the studies recruited small numbers of NPDR and PDR patients (n = 19-473)5,18–20 or exclusively PDR subjects (n = 9-42).4,21–24 Although ANGPTL4 has been found increased in PDR patients, the number of patients ranged from 28 to 53.4,20,24
Manuscript no. 2011-1038.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported in part by National Institutes of Health grant R01 EY014684 GOLDR, BioEye grant from the Eye Birth Defects Foundation, Clinical and Translational Sciences Institute grant UL1RR033176, and Diabetes Endocrinology Research Center grant P30 DK063491. The sponsor or funding organization had no role in the design or conduct of this research.