Brief ReportMean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
Section snippets
Subjects
The study population has been described previously.10 In brief, T2DM subjects and control unrelated subjects were recruited from the Boston metropolitan area; these participants were identified through physicians and clinics associated with the Partners Healthcare System and through newspaper advertisements. Subjects reported their medication history, personal and family history of diseases, smoking status, physical activity, and other lifestyle exposures. Blood pressure, height, weight, waist
Results
The clinical and demographic characteristics of the study participants are shown in Table I. As expected, the case subjects had a higher prevalence of traditional risk factors than did the control subjects. The observed loge-TSR was significantly smaller in the cases than the controls (P = 0.003; Table I). In a multivariable linear regression analysis among the control subjects, an inverse association was observed between the loge-TSR and BMI (P = 0.04; Table II). Moreover, in the logistic
Conclusions
The current investigation has shown that mean leukocyte telomere shortening was associated with T2DM. We also found an inverse association between mean leukocyte telomere length and BMI among our control subjects, thus in concordance with previous reports.12, 13, 14, 15, 16 However, we did not find any association of mean leukocyte telomere length with several diabetes-related intermediate phenotypes among our control subjects; this may be partly because of the current stringent selection
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Supported by F. Hoffmann La-Roche.