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Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

Nature volume 381, pages 706–709 (1996)Cite this article

Abstract

NEUROTROPHINS promote neuronal survival and differentiation, but the fact that their expression is modified by neuronal activity, suggests a role in regulating synapse development and plasticity1–3. In developing hippocampus, the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB4–7 increases in parallel with the ability to undergo long-term potentiation (LTP)8–10. Here we report a mechanism by which BDNF modulates hippocampal LTP. Exogenous BDNF promoted the induction of LTP by tetanic stimulation in young (postnatal day 12–13) hippocampal slices, which in the absence of BDNF show only short-term potentiation (STP). This effect was due to an enhanced ability of hippocampal synapses to respond to tetanic stimulation, rather than to a direct modulation of the LTP-triggering mechanism. A TrkB–IgG fusion protein, which scavenges endogenous BDNF11, reduced the synaptic responses to tetanus as well as the magnitude of LTP in adult hippocampus. Our results suggest that BDNF may regulate LTP in developing and adult hippocampus by enhancing synaptic responses to tetanic stimulation.

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Author notes

  1. Lucas D. Pozzo-Miller

    Present address: Laboratory of Neurobiology, NINDS, National Institues of Health, Bethesda, Maryland, 20892, USA

Authors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, 07110

    Alexander Figurov, Lucas D. Pozzo-Miller, Petur Olafsson, Ti Wang & Bai Lu

  2. Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Alexander Figurov, Lucas D. Pozzo-Miller, Petur Olafsson, Ti Wang & Bai Lu

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Figurov, A., Pozzo-Miller, L., Olafsson, P. et al. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381, 706–709 (1996). https://doi.org/10.1038/381706a0

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