Abstract
Potential long-term negative effects of increased vitamin D consumption are not thoroughly examined. The aim of this study was to investigate possible negative effects of vitamin D supplementation on serum lipids and lipoproteins. A 1-year long randomised double-blinded placebo-controlled intervention study with two doses of vitamin D3 (10 and 20 μg/day) was carried out among 89 women (18–53 years of age) and 84 men (18–64 years of age) of Pakistani origin living in Denmark with low vitamin D status. This study did not find changes in total cholesterol, LDL-cholesterol, HDL-cholesterol, LDL-cholesterol/HDL-cholesterol ratio, VLDL-cholesterol and triacylglycerol after daily supplementation with 10 or 20 μg vitamin D for 1 year. In conclusion, increasing the vitamin D intake by 10–20 μg per day for 1 year is safe for Pakistani immigrants with regards to serum lipids and lipoproteins.
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Acknowledgements
We thank Karin Hess Ygil, Dorthe Strange and Nighat Kwajada for the sampling, and Jette Jakobsen for analysing 25-hydroxyvitamin D. The study is an addition to the OPTIFORD-project ‘Towards a strategy for optimal vitamin D fortification’, financed by EU, the Fifth Framework Programme (QLK1-CT-2000-00623).This study was sponsored by the European Fifth Framework Programme (QLK1-CT-2000-00623) and National Food Institute, Technical University of Denmark. The material has not been submitted for publication elsewhere while under consideration for the European Journal of Clinical Nutrition.
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Guarantor: R Andersen.
Contributors: RA collected the data, wrote the paper and undertook the statistical analyses. RA, CB, CM, LTS and LO designed the study. HM and ET facilitated the completion of the study. All contributed to the paper.
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Andersen, R., Brot, C., Mejborn, H. et al. Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants. Eur J Clin Nutr 63, 1150–1153 (2009). https://doi.org/10.1038/ejcn.2009.18
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DOI: https://doi.org/10.1038/ejcn.2009.18
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