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Altered hypothalamic function in diet-induced obesity

International Journal of Obesity volume 35, pages 1455–1465 (2011)Cite this article

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Abstract

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure.

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  1. Laboratory of Cell Signaling, University of Campinas, Campinas, São Paulo, Brazil,

    L A Velloso

  2. Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, USA,

    M W Schwartz

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Correspondence to L A Velloso.

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Velloso, L., Schwartz, M. Altered hypothalamic function in diet-induced obesity. Int J Obes 35, 1455–1465 (2011). https://doi.org/10.1038/ijo.2011.56

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  • DOI: https://doi.org/10.1038/ijo.2011.56

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