Elsevier

Kidney International

Volume 73, Issue 9, 1 May 2008, Pages 989-991
Kidney International

Commentary
Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?

https://doi.org/10.1038/ki.2008.104Get rights and content
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Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PPi), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PPi by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.

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