The paradigm that obesity at any age is protective against skeletal failure has been ingrained in clinical practice for several decades. A new study published in the Journal of Bone and Mineral Research challenges the basic framework of that tenet.
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References
Dimitri, P., Wales, J. K. & Bishop, N. Fat and bone in children—differential effects of obesity on bone size and mass according to fracture history. J. Bone Miner. Res. doi:10.1359/jbmr.090823.
World Health Organization Collaborating Centre for Metabolic Bone Diseases WHO Fracture Risk Assessment Tool [online] (2009).
von Muhlen, D., Safii, S., Jassal, S. K., Svartberg, J. & Barrett-Connor, E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo study. Osteoporos. Int. 18, 1337–1344 (2007).
Hsu, Y. H. et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am. J. Clin. Nutr. 83, 146–154 (2006).
Goulding, A. et al. Bone mineral density in girls with forearm fractures. J. Bone Miner. Res. 13, 143–148 (1998).
Nagasaki, K., Kikuchi, T., Hiura, M. & Uchiyama, M. Obese Japanese children have low bone mineral density after puberty. J. Bone Miner. Metab. 22, 376–381 (2004).
Gilsanz, V. et al. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J. Clin. Endocrinol. Metab. 94, 3387–3393 (2009).
Janicka, A. et al. Fat mass is not beneficial to bone in adolescents and young adults. J. Clin. Endocrinol. Metab. 92, 143–147 (2007).
Elbaz, A., Wu, X., Rivas, D., Gimble, J. M. & Duque, G. Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J. Cell. Mol. Med. doi:10.1111/j.1582–49342009.00751.x.
Sul, H. S. Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate. Mol. Endocrinol. 23, 1717–1725 (2009).
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Kawai, M., Rosen, C. Adiposity and bone accrual—still an established paradigm?. Nat Rev Endocrinol 6, 63–64 (2010). https://doi.org/10.1038/nrendo.2009.249
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DOI: https://doi.org/10.1038/nrendo.2009.249
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