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An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study

International Journal of Obesity volume 28, pages 462–469 (2004)Cite this article

Abstract

OBJECTIVE: To examine genetic loci linked to a long-term burden and trend of obesity traits, such as body mass index (BMI), from childhood to adulthood.

DESIGN: Longitudinal study using serial measurements of BMI from childhood.

SUBJECTS: A total of 782 unselected white siblings (representing 521 full and 39 half sib-pairs) from 342 families enrolled in the Bogalusa Heart Study.

MEASUREMENTS: A total of 357 microsatellite markers with an average spacing of 9.0 cM spanning the 22 autosomal chromosomes were typed. A quadratic growth curve was developed using a random effects model based on serial measurements of BMI from childhood to adulthood. The serial changes in BMI were measured in terms of long-term burden (area under the curve (AUC) divided by follow-up years) and the long-term trend (incremental AUC, calculated as total AUC−baseline AUC).

RESULTS: Heritability estimates of long-term measures were 0.78 for total AUC and 0.43 for incremental AUC. In a variance-component-based multipoint linkage analysis with SOLAR, linkage to the long-term measures of BMI was observed on chromosomes 1, 5, 7, 12, 13 and 18. For total AUC, LOD scores were 3.0 at 110 cM on chromosome 12, 2.9 at 26 cM and 2.4 at 52 cM on chromosome 7, and 2.2 at 126 cM on chromosome 5. For incremental AUC, LOD scores were 2.9 at 26 cM, 2.1 at 97 cM and 2.3 at 110 cM on chromosome 12, 2.2 at 69 cM on chromosome 7, 2.2 at 91 cM and 2.5 at 150 cM on chromosome 1, 2.0 at 119 cM on chromosome 5, 2.0 at 54 cM on chromosome 13 and 2.0 at 7 cM on chromosome 18. Several important obesity-related candidate genes are located in the regions or near the markers showing positive linkage.

CONCLUSION: Linkage evidence found in this study indicates that regions on these chromosomes might harbor genetic loci that affect the propensity to develop obesity from childhood.

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Acknowledgements

This study was supported by grants HL-38844 from the National Heart, Lung, and Blood Institute and AG-16592 from the National Institute on Aging.

Some of the results of this paper were obtained by using the program package S.A.G.E., which is supported by a U.S. Public Health Service Research Resource Grant (1 P41 RR03655) from the National Center for Research Resources.

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Authors and Affiliations

  1. Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane School of Public Health & Tropical Medicine, New Orleans, LA, USA

    W Chen, S Li, S R Srinivasan & G S Berenson

  2. Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

    N R Cook

  3. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA

    B A Rosner

  4. Human Genetics Center and Institute of Molecular Medicine, University of Texas-Houston Health Science Center, Houston, TX, USA

    E Boerwinkle

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Correspondence to G S Berenson.

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Chen, W., Li, S., Cook, N. et al. An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study. Int J Obes 28, 462–469 (2004). https://doi.org/10.1038/sj.ijo.0802610

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