Original InvestigationPathogenesis and Treatment of Kidney DiseaseTime-Dependent Association Between Metabolic Syndrome and Risk of CKD in Korean Men Without Hypertension or Diabetes
Section snippets
Study Population
The study population was composed of Korean working men and was described in detail previously.19, 20 The study population included workers 40 years or older who underwent an annual comprehensive health examination and workers 30 to 39 years who underwent a biennial comprehensive health examination. In 2002, a total of 15,347 workers aged 30 to 59 years participated in the comprehensive health examination at a university hospital in Seoul, Korea. A total of 3,320 men were excluded from the
Results
At baseline, mean age of the 10,685 participants in the analytic cohort was 37.0 ± 4.8 years (range, 30 to 59 years). During follow-up, 7 men died of nonrenal diseases. Six of these men were not included in the analytic cohort. Men who did not participate in follow-up examinations (n = 1,342) were on average 0.8 years older and more likely to be current smokers and current consumers of alcohol than those included in the analytic cohort. None of the other variables differed between participants
Discussion
In the present prospective study of nonhypertensive and nondiabetic Korean men, metabolic syndrome at baseline was associated with the development of CKD, and this relationship was observed even after updating the status of metabolic syndrome on follow-up. In addition, there were graded relationships between number of metabolic syndrome traits or quintiles of HOMA-IR over time as a time-dependent variable and risk of CKD. Increased triglyceride and low HDL-C levels among metabolic syndrome
Acknowledgements
Support: This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD; KRF-2006-331-E00090).
Financial Disclosure: None.
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Originally published online as doi:10.1053/j.ajkd.2008.07.027 on October 6, 2008.