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Horm Metab Res 1989; 21(7): 376-382
DOI: 10.1055/s-2007-1009242
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Serum Levels of Apolipoprotein A-I, A-II and HDL-Cholesterol in Second Half of Normal Pregnancy and in Pregnancy Complicated by Pre-Eclampsia

U. Rosing1 , G. Samsioe2 , A. Ölund1 , B. Johansson3 , A. Kallner3
  • 1Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Huddinge
  • 2Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Gothenburg
  • 3Department of Clinical Chemistry, Karolinska Insitutet, Karolinska University Hospital, Stockholm, Sweden
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Publication History

1988

1988

Publication Date:
14 March 2008 (online)

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Summary

Serum concentrations of Apolipoprotein A-I and A-II, (Apo A-1 and Apo A-II) HDL-cholesterol (HDL-C), Total Cholesterol (TC), triglycerides (TG) and lipoproteinelectrophoresis were assayed serially in the second half of normal pregnancy (21 women), in pre-eclampsia (26 women) and in both groups one and six weeks after delivery.

In the normal group we found increased concentrations of Apo A-I and HDL-C, which remained unaltered during pregnancy. Apo A-II was unchanged. Correlation coefficients for Apo A-II vs HDL-C and Apo A-I vs Apo A-II decreased gradually towards delivery while it remained at an elevated and unaltered level for Apo A-I vs HDL-C. The Apo A-I/HDL-C ratio was unaltered during the whole study while the Apo A-I/A-II ratio was elevated during pregnancy and the Apo A-II/HDL-C ratio was reduced. These results may indicate a gradual change in the surface structure of the HDL particle or its subfractions.

In pre-eclampsia Apo A-I and HDL-C concentrations were reduced, TG was increased and Apo A-II and TC were unchanged when compared with the normal pregnancy group. A more pronounced correlation coefficient was recorded for Apo A-I vs HDL-C than for Apo A-II vs HDL-C and Apo A-I vs Apo II. The results indicate that from an atherogenic point of view normal pregnancy seems more beneficial than pre-eclampsia.

Key-Words

Apolipoprotein A-I and A-II - HDL-Cholesterol - Serum Lipids - Pregnancy - Puerperium - Pre-Eclampsia

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