Elsevier

Kidney International

Volume 67, Issue 4, April 2005, Pages 1489-1499
Kidney International

Clinical Nephrology – Epidemiology – Clinical Trials
Renal replacement therapy for diabetic end-stage renal disease: Data from 10 registries in Europe (1991–2000)

https://doi.org/10.1111/j.1523-1755.2005.00227.xGet rights and content
Under an Elsevier user license
open archive

Renal replacement therapy for diabetic end-stage renal disease: Data from 10 registries in Europe (1991–2000).

Background

There is concern about the rising prevalence of type 2 diabetes mellitus and of the resultant nephropathy. This study uses data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry to provide information on the epidemiology and outcome of renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetic nephropathy (DN).

Methods

Data from the following 10 registries: Austria, French-speaking Belgium, Denmark, Finland, Greece, Norway, Scotland (UK), Catalonia (Spain), Sweden, and The Netherlands were combined. Average annual changes (%) were estimated by Poisson regression. Analyses of mortality were performed by Cox regression.

Results

An increase in patients with type 2 DN entering RRT has been observed (+11.9% annually, P < 0.05), while large differences in RRT incidence in this disease continue to exist between countries in Europe. There was a reduction in mortality during the first 2 years on dialysis therapy among patients with type 2 DN (AHR 0.96, 95%CI 0.94–0.97 annually). The mortality among transplant recipients decreased for both type 1 DN and nondiabetic ESRD (non DN) within the 1995–1998 cohort (type 1 DN: AHR 0.49, 95% CI 0.35–0.68; non DN: AHR 0.79, 95% CI 0.69–0.90) compared to the 1991–1994 cohort.

Conclusion

This report has shown that during the last decade there has been a marked increase in the incidence of RRT for type 2 DN. Survival analysis showed that over the period 1991–1999 the mortality rates of all dialysis patients and of type 1 diabetic and nondiabetic renal transplant recipients have fallen.

Keywords

diabetic nephropathy
epidemiology
dialysis
mortality
renal replacement therapy
renal transplantation

Cited by (0)