Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Koichiro Kadota; Noboru Takamura; Kiyoshi Aoyagi; Hironori Yamasaki; Toshiro Usa; Mio Nakazato; Takahiro Maeda; Mitsuhiro Wada; Ken-ichiro Nakashima; Koh Abe; Fuminao Takeshima; Yoshiyuki Ozono

doi:10.1253/circj.72.304

Clinical Investigation

Availability of Cardio-Ankle Vascular Index (CAVI) as a Screening Tool for Atherosclerosis

Koichiro Kadota, Noboru Takamura, Kiyoshi Aoyagi, Hironori Yamasaki, Toshiro Usa, Mio Nakazato, Takahiro Maeda, Mitsuhiro Wada, Ken-ichiro Nakashima, Koh Abe, Fuminao Takeshima, Yoshiyuki Ozono

Author information

Koichiro Kadota
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
Noboru Takamura
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
Kiyoshi Aoyagi
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
Hironori Yamasaki
Health Center, Nagasaki University
Toshiro Usa
Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
Mio Nakazato
Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
Takahiro Maeda
Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
Mitsuhiro Wada
Department of Clinical Pharmacy, Nagasaki University Graduate School of Biomedical Sciences
Ken-ichiro Nakashima
Department of Clinical Pharmacy, Nagasaki University Graduate School of Biomedical Sciences
Koh Abe
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
Fuminao Takeshima
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences
Yoshiyuki Ozono
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences

Keywords: Atherosclerosis, Cardio-ankle vascular index (CAVI), Carotid intima - media thickness (CIMT), Homocysteine (HCY)

JOURNAL FREE ACCESS

2008 Volume 72 Issue 2 Pages 304-308

DOI https://doi.org/10.1253/circj.72.304

Details

Abstract

Background A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial - ankle pulse wave velocity and blood pressure. Methods and Results In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima - media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A_1c and total HCY, as well as CIMT. Conclusion CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it. (Circ J 2008; 72: 304 - 308)

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