Higher magnification lenses versus conventional lenses for evaluation of diabetic neuropathy by corneal in vivo confocal microscopy

Drew A Hume; Leif Erik Lovblom; Ausma Ahmed; Emily Yeung; Andrej Orszag; Tae Maen Shin; Vera Bril; Bruce A Perkins

doi:10.1016/j.diabres.2012.04.010

Higher magnification lenses versus conventional lenses for evaluation of diabetic neuropathy by corneal in vivo confocal microscopy

Diabetes Res Clin Pract. 2012 Aug;97(2):e37-40. doi: 10.1016/j.diabres.2012.04.010. Epub 2012 May 10.

Authors

Drew A Hume¹, Leif Erik Lovblom, Ausma Ahmed, Emily Yeung, Andrej Orszag, Tae Maen Shin, Vera Bril, Bruce A Perkins

Affiliation

¹ Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Canada.

PMID: 22579213
DOI: 10.1016/j.diabres.2012.04.010

Abstract

We tested agreement for small fibre morphology using corneal in vivo confocal microscopy between the recently available higher-magnification 300 μm(2) and the conventional 400 μm(2) field-of-view lenses. We found insignificant bias for corneal nerve fibre length indicating that either lens could reasonably be applied to research and clinical screening for diabetic neuropathy.

Publication types

Comparative Study

MeSH terms

Adult
Cornea / pathology*
Cornea / physiopathology
Diabetes Mellitus, Type 1 / pathology*
Diabetic Neuropathies / pathology*
Diabetic Neuropathies / physiopathology
Female
Humans
Male
Microscopy, Confocal / instrumentation
Microscopy, Confocal / methods*
Nerve Fibers / pathology*
Reproducibility of Results