Abstract
Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFα and IL6). Baseline vitamin-D and 2h blood glucose independently predicted progression to diabetes.
Keywords:
Diabetes; Insulin resistance; Prediabetes; Systemic inflammation; Vitamin-D.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Blood Glucose / analysis
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / mortality
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Diabetes Mellitus, Type 2 / prevention & control*
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Dietary Supplements
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Disease Progression
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Female
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Follow-Up Studies
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Humans
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India
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Inflammation / drug therapy
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Inflammation / mortality
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Inflammation / prevention & control*
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Insulin Resistance*
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Male
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Middle Aged
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Prediabetic State / blood
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Prediabetic State / drug therapy*
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Prognosis
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Prospective Studies
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Survival Rate
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Vitamin D / administration & dosage*
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Vitamin D Deficiency / mortality
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Vitamin D Deficiency / prevention & control
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Vitamins / administration & dosage*
Substances
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Blood Glucose
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Vitamins
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Vitamin D