The target of metformin in type 2 diabetes

N Engl J Med. 2014 Oct 16;371(16):1547-8. doi: 10.1056/NEJMcibr1409796.
No abstract available

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / metabolism*
  • Dihydroxyacetone Phosphate / metabolism
  • Gluconeogenesis / drug effects*
  • Glycerolphosphate Dehydrogenase / antagonists & inhibitors*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Hypoglycemic Agents / therapeutic use
  • Lactic Acid / metabolism
  • Liver / drug effects
  • Liver / enzymology*
  • Metformin / pharmacology*
  • Metformin / therapeutic use
  • Mitochondria / enzymology
  • Rats

Substances

  • Hypoglycemic Agents
  • Lactic Acid
  • Dihydroxyacetone Phosphate
  • Metformin
  • Glycerolphosphate Dehydrogenase