Survival of diabetes patients with major amputation is comparable to malignant disease

Diab Vasc Dis Res. 2015 Jul;12(4):265-71. doi: 10.1177/1479164115579005. Epub 2015 Apr 28.

Abstract

Introduction: Almost all studies on diabetic foot syndrome focused on prevention of amputation and did not investigate long-term prognosis and survival of patients as a primary outcome parameter.

Methods: We did a retrospective cohort study including 314 patients who had diabetic foot syndrome and underwent amputation between December 1995 and January 2001.

Results: A total of 48% of patients received minor amputation (group I), 15% only major amputation (group II) and 36% initially underwent a minor amputation that was followed by a major amputation (group III). Statistically significant differences were observed in comparison of the median survival of group I to group II (51 vs. 40 months; p = 0.016) and of group II to group III (40 vs. 55 months; p = 0.003).

Discussion: The prognosis of patients with major amputation due to diabetic foot syndrome is comparable to patients with malignant diseases. Vascular interventions did not improve the individual prognosis of patients.

Keywords: Diabetes mellitus; diabetic foot ulcer; major amputation; minor amputation; survival.

Publication types

  • Clinical Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amputation, Surgical / methods*
  • Cardiovascular Diseases / epidemiology*
  • Cohort Studies
  • Comorbidity
  • Diabetes Mellitus / epidemiology*
  • Diabetic Foot / epidemiology
  • Diabetic Foot / surgery*
  • Diabetic Nephropathies / epidemiology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Mortality*
  • Neoplasms / surgery
  • Prognosis
  • Retrospective Studies
  • Survival Rate