Fifteen women (20- to 23-yr.-old), engaged in an intensive 6- to 8-wk. endurance running program, progressively increased distance from 20 miles during the first week to 50 miles during the fifth week and thereafter. Before (T1), during (T2), and after training (T3), submaximal treadmill runs of 1-hr. duration subdivided into three successive 20-min. segments were completed at approximately 60, 70, and 80% of maximal oxygen uptake, respectively. Ratings of perceived exertion (RPE) were differentiated to obtain local (L), central (C), and over-all (O) responses during these 20-min. segments. Subjects rated the effort during the final 30 sec. of each 5-min. interval. Upon completion of each exercise segment, blood samples were drawn for analysis of lactate (Hla), epinephrine (E), and norepinephrine (NE) to determine the relationship between the differentiated RPEs and these stress markers. Endurance training significantly lowered central and over-all ratings of perceived exertion between T1 and T3 runs but no change occurred in the L-RPE responses to muscular and joint strain. Significant correlations between the stress markers and RPE pooled across sessions were observed during the three treadmill sessions (Hla vs L-RPE, eta = 0.68; E vs C-RPE, eta = 0.54; and NE vs C-RPE, eta = 0.63). These findings indicate that central and over-all ratings of perceived exertion may be more readily influenced by intensive endurance training than local ratings. In addition, while lactate levels may be related to local ratings of perceived exertion, catecholamine levels appear to be associated with central ratings.