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Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity.
Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y. Ishikawa K, et al. Among authors: ikeniwa m. PLoS One. 2015 Feb 6;10(2):e0115350. doi: 10.1371/journal.pone.0115350. eCollection 2015. PLoS One. 2015. PMID: 25658116 Free PMC article.
Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function.
Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y. Izumoto-Akita T, et al. Among authors: ikeniwa m. BMJ Open Diabetes Res Care. 2015 Oct 19;3(1):e000128. doi: 10.1136/bmjdrc-2015-000128. eCollection 2015. BMJ Open Diabetes Res Care. 2015. PMID: 26504525 Free PMC article.