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The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis.
El Mehdi M, Takhlidjt S, Devère M, Arabo A, Le Solliec MA, Maucotel J, Bénani A, Nedelec E, Duparc C, Lefranc B, Leprince J, Anouar Y, Prévost G, Chartrel N, Picot M. El Mehdi M, et al. Among authors: takhlidjt s. Diabetologia. 2022 Jul;65(7):1198-1211. doi: 10.1007/s00125-022-05706-5. Epub 2022 Apr 27. Diabetologia. 2022. PMID: 35476025
Acute but Not Chronic Central Administration of the Neuropeptide 26RFa (QRFP) Improves Glucose Homeostasis in Obese/Diabetic Mice.
Le Solliec MA, Arabo A, Takhlidjt S, Maucotel J, Devère M, Riancho J, Berrahmoune H, do Rego JL, do Rego JC, Bénani A, Nedelec E, Lefranc B, Leprince J, Anouar Y, Picot M, Chartrel N, Prévost G. Le Solliec MA, et al. Among authors: takhlidjt s. Neuroendocrinology. 2022;112(11):1104-1115. doi: 10.1159/000522287. Epub 2022 Jan 28. Neuroendocrinology. 2022. PMID: 35093951 Free article.
Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).
El-Mehdi M, Takhlidjt S, Khiar F, Prévost G, do Rego JL, do Rego JC, Benani A, Nedelec E, Godefroy D, Arabo A, Lefranc B, Leprince J, Anouar Y, Chartrel N, Picot M. El-Mehdi M, et al. Among authors: takhlidjt s. BMJ Open Diabetes Res Care. 2020 Feb;8(1):e000942. doi: 10.1136/bmjdrc-2019-000942. BMJ Open Diabetes Res Care. 2020. PMID: 32114486 Free PMC article.
Interactions between the regulatory peptide 26RFa (QRFP) and insulin in the regulation of glucose homeostasis in two complementary models: The high fat 26RFa-deficient mice and the streptozotocin insulin-deficient mice.
Le Solliec MA, Arabo A, Takhlidjt S, Maucotel J, Devère M, Berrahmoune H, Bénani A, Nedelec E, Lefranc B, Leprince J, Picot M, Chartrel N, Prévost G. Le Solliec MA, et al. Among authors: takhlidjt s. Neuropeptides. 2023 Apr;98:102326. doi: 10.1016/j.npep.2023.102326. Epub 2023 Feb 9. Neuropeptides. 2023. PMID: 36791581