Drug repositioning is a highly studied alternative strategy to discover and develop
anticancer drugs. This drug development approach identifies new indications for existing …

Introduction: Cancer cells have increased glycolysis and glutaminolysis. Their third feature is
increased de novo lipogenesis. As such, fatty acid (FA) synthesis enzymes are over …

Calreticulin (CRT) is a pleiotropic and highly conserved molecule that is mainly localized in
the endoplasmic reticulum. Recently, CRT has gained special interest for its functions …

Objective Obesity is associated with metabolic abnormalities, including insulin resistance
and dyslipidemias. Previous studies demonstrated that genistein intake modifies the gut …

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other
neurological disorders in the past 50 years. Recent evidence has shown the potential of …

Cachexia is a multifactorial paraneoplastic syndrome commonly associated with advanced
stages of cancer. Cachexia is responsible for poor responses to antitumoral treatment and …

Complex common diseases are a significant burden for our societies and demand not only
preventive measures but also more effective, safer, and more affordable treatments. The …

Purpose Ivermectin is an antiparasitic drug that exhibits antitumor effects in preclinical
studies, and as such is currently being repositioned for cancer treatment. However …

Drug repurposing has increased in recent years as an attractive option for treating a number
of diseases. Compared to those brought forward via traditional chemical development, drugs …

Background Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting
from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of …