[HTML][HTML] Sex differences in the risk of vascular disease associated with diabetes
R de Ritter, M de Jong, RC Vos… - Biology of sex …, 2020 - Springer
Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the
relative risk of vascular disease associated with diabetes is substantially higher in women …
relative risk of vascular disease associated with diabetes is substantially higher in women …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
[HTML][HTML] Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?
CJH van der Kallen, MMJ van Greevenbroek… - Apoptosis, 2009 - Springer
Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized by
hyperglycaemia. Several different mechanisms have been implicated in the development of …
hyperglycaemia. Several different mechanisms have been implicated in the development of …
Identification of context-dependent expression quantitative trait loci in whole blood
Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology,. Expression quantitative trait loci (eQTLs) help to explain the regulatory …
on disease etiology,. Expression quantitative trait loci (eQTLs) help to explain the regulatory …
[HTML][HTML] Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study
JD Van der Berg, CDA Stehouwer, H Bosma… - Diabetologia, 2016 - Springer
Aims/hypothesis The study investigated cross-sectional associations of total amount and
patterns of sedentary behaviour with glucose metabolism status and the metabolic …
patterns of sedentary behaviour with glucose metabolism status and the metabolic …
[HTML][HTML] Blood lipids influence DNA methylation in circulating cells
Background Cells can be primed by external stimuli to obtain a long-term epigenetic
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …
[PDF][PDF] DNA methylation analysis identifies loci for blood pressure regulation
Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
with blood pressure (BP), but sequence variation accounts for a small fraction of the …
Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht Study
BM Sörensen, AJHM Houben, TTJM Berendschot… - Circulation, 2016 - Am Heart Assoc
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular
disease. This can be partly explained by large-artery dysfunction, which already occurs in …
disease. This can be partly explained by large-artery dysfunction, which already occurs in …
Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and …
KHJ Gaens, GH Goossens, PM Niessen… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Dysregulation of inflammatory adipokines by the adipose tissue plays an
important role in obesity-associated insulin resistance. Pathways leading to this …
important role in obesity-associated insulin resistance. Pathways leading to this …
[PDF][PDF] Improving phenotypic prediction by combining genetic and epigenetic associations
We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …
mass index (BMI) and height and whether they predict these phenotypes over and above …