[HTML][HTML] Sex differences in the risk of vascular disease associated with diabetes

R de Ritter, M de Jong, RC Vos… - Biology of sex …, 2020 - Springer
Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the
relative risk of vascular disease associated with diabetes is substantially higher in women …

Disease variants alter transcription factor levels and methylation of their binding sites

MJ Bonder, R Luijk, DV Zhernakova, M Moed… - Nature …, 2017 - nature.com
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …

[HTML][HTML] Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?

CJH van der Kallen, MMJ van Greevenbroek… - Apoptosis, 2009 - Springer
Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized by
hyperglycaemia. Several different mechanisms have been implicated in the development of …

Identification of context-dependent expression quantitative trait loci in whole blood

DV Zhernakova, P Deelen, M Vermaat, M Van Iterson… - Nature …, 2017 - nature.com
Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology,. Expression quantitative trait loci (eQTLs) help to explain the regulatory …

[HTML][HTML] Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study

JD Van der Berg, CDA Stehouwer, H Bosma… - Diabetologia, 2016 - Springer
Aims/hypothesis The study investigated cross-sectional associations of total amount and
patterns of sedentary behaviour with glucose metabolism status and the metabolic …

[HTML][HTML] Blood lipids influence DNA methylation in circulating cells

KF Dekkers, M van Iterson, RC Slieker, MH Moed… - Genome biology, 2016 - Springer
Background Cells can be primed by external stimuli to obtain a long-term epigenetic
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …

[PDF][PDF] DNA methylation analysis identifies loci for blood pressure regulation

MA Richard, T Huan, S Ligthart, R Gondalia… - The American Journal of …, 2017 - cell.com
Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht Study

BM Sörensen, AJHM Houben, TTJM Berendschot… - Circulation, 2016 - Am Heart Assoc
Background: Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular
disease. This can be partly explained by large-artery dysfunction, which already occurs in …

Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and …

KHJ Gaens, GH Goossens, PM Niessen… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Dysregulation of inflammatory adipokines by the adipose tissue plays an
important role in obesity-associated insulin resistance. Pathways leading to this …

[PDF][PDF] Improving phenotypic prediction by combining genetic and epigenetic associations

S Shah, MJ Bonder, RE Marioni, Z Zhu… - The American Journal of …, 2015 - cell.com
We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …