The oxidation of glucose represents a major source of metabolic energy for mammaliancells.
However, because the plasma membrane is impermeable to polar molecules such as …

Emerging evidence has suggested that the capability of a tumor to grow and propagate is
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …

The stimulation of insulin secretion by glucose can be modulated by multiple nutritive,
hormonal, and pharmacological inputs. Fatty acids potentiate insulin secretion through the …

Mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene.
The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine …

Immune cells are somewhat unique in that activation responses can alter quantitative
phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations …

Dehydroascorbic acid (DHA) is rapidly taken up by cells and reduced to ascorbic acid (AA).
Using the Xenopus laevis oocyte expression system we examined transport of DHA and AA …

The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis
of organisms and cells. The sterol regulatory element-binding protein (SREBP) transcription …

Cerebral palsy (CP) is caused by an insult to or malformation of the developing brain which
affects motor control centers and causes alterations in growth, development, and overall …

Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …

Heightened impulsivity and inefficient inhibitory control are increasingly recognized as risk
factors for unhealthy eating and obesity but the underlying processes are not fully …