Periodontal disease and diabetes mellitus: the role of tumor necrosis factor‐α in a 2‐way relationship
F Nishimura, Y Iwamoto, J Mineshiba… - Journal of …, 2003 - Wiley Online Library
It is generally accepted that obesity is associated with many other multiple‐risk factor
syndromes such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and periodontal …
syndromes such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and periodontal …
Periodontal disease as a complication of diabetes mellitus
F Nishimura, K Takahashi, M Kurihara… - Annals of …, 1998 - Wiley Online Library
Based on our clinical observations that patients with insulin‐dependent diabetes mellitus
(IDDM) are subject to periodontal disease, we developed the hypothesis that hyper‐or …
(IDDM) are subject to periodontal disease, we developed the hypothesis that hyper‐or …
Diabetes as a risk factor for periodontal disease—plausible mechanisms
D Polak, T Sanui, F Nishimura… - Periodontology 2000, 2020 - Wiley Online Library
The present narrative review examines the scientific evidence of the biological mechanisms
that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding …
that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding …
A proposed model linking inflammation to obesity, diabetes, and periodontal infections
RJ Genco, SG Grossi, A Ho, F Nishimura… - Journal of …, 2005 - Wiley Online Library
Background: Obesity is an important risk factor for diabetes, cardiovascular disease, and
periodontal disease. Adipocytes appear to secrete proinflammatory cytokines which may be …
periodontal disease. Adipocytes appear to secrete proinflammatory cytokines which may be …
Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene …
H Maeda, C Fujimoto, Y Haruki, T Maeda… - FEMS Immunology & …, 2003 - academic.oup.com
Accurate quantification of bacterial species in dental plaque is needed for microbiological
diagnosis of periodontal diseases. The present study was designed to assess the sensitivity …
diagnosis of periodontal diseases. The present study was designed to assess the sensitivity …
The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor‐alpha and glycated hemoglobin level in patients with type 2 diabetes
Y Iwamoto, F Nishimura, M Nakagawa… - Journal of …, 2001 - Wiley Online Library
Background: Tumor necrosis factor‐α (TNF‐α) may play an important role in insulin
resistance. In this study, we hypothesized that TNF‐α produced due to periodontal …
resistance. In this study, we hypothesized that TNF‐α produced due to periodontal …
[HTML][HTML] Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss
Y Nakao, T Fukuda, Q Zhang, T Sanui, T Shinjo, X Kou… - Acta biomaterialia, 2021 - Elsevier
Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free
therapeutics involving MSCs and the contents can be customized under disease-associated …
therapeutics involving MSCs and the contents can be customized under disease-associated …
Tumor necrosis factor‐alpha gene (TNF‐α) −1031/−863, −857 single‐nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese
Y Soga, F Nishimura, H Ohyama… - Journal of clinical …, 2003 - Wiley Online Library
Objectives: Tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) participate in the
establishment of inflammatory lesions in periodontitis. High production of these cytokines …
establishment of inflammatory lesions in periodontitis. High production of these cytokines …
Antimicrobial periodontal treatment decreases serum C‐reactive protein, tumor necrosis factor‐alpha, but not adiponectin levels in patients with chronic periodontitis
Y Iwamoto, F Nishimura, Y Soga… - Journal of …, 2003 - Wiley Online Library
Background: Elevated levels of C‐reactive protein (CRP) and decreased plasma
adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent …
adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent …
Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues
S Suzuki, N Haruyama, F Nishimura, AB Kulkarni - Archives of oral biology, 2012 - Elsevier
Dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) are highly
phosphorylated proteins that belong to the family of small integrin-binding ligand N-linked …
phosphorylated proteins that belong to the family of small integrin-binding ligand N-linked …