Background Recently, attention has been focused on molecular targeted cancer therapy in
various tumors. Although there is no single consistent molecular target specific for oral …

While the significance of large cervical node metastases in patients with head and neck
squamous carcinomas is well established, the import of a finding of regional nodal …

We examined the role of chemokine signaling on the lymph node metastasis of oral
squamous cell carcinoma (SCC) using lymph node metastatic (HNt and B88) and …

DNA‐PK is a nuclear protein with serine/threonine kinase activity and forms a complex
consisting of the DNA‐PKcs and a heterodimer of Ku70 and Ku80 proteins. Recent …

Vascular endothelial growth factor (VEGF) A is known to play an important role in tumor
angiogenesis. The additional members of the VEGF family, VEGF B, C and D have been …

Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has
shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast …

Tumor-associated macrophages (TAMs) have been shown to display both positive and
negative effects on tumor growth of various cancer. In this study, TAMs were …

Purpose We investigated whether serum interleukin (IL)-8 reflects the tumor
microenvironment and has prognostic value in patients with oral squamous cell carcinoma …

FAT1 [Homo sapiens FAT tumor suppressor homolog 1 (Drosophila)] is an intrinsic
membrane protein classified as a member of the cadherin superfamily. The FAT1 gene is a …

The support mechanisms that are involved in lymph-node metastasis of oral squamous cell
carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor …