The association of cdk4 with D-type cyclins to form functional kinase complexes is
comparatively inefficient. This has led to the suggestion that assembly might be a regulated …

Genomic Southern blots of DNA from eight strains of mice were examined for restriction
fragment length polymorphisms in their loci encoding the variable region of the T-cell …

Cell cycle progression is controlled by the sequential functions of cyclin-dependent kinases
(cdks). Cdk activation requires phosphorylation of a key residue (on sites equivalent to Thr …

Youth-onset type 2 diabetes (T2D) is increasingly recognized as a disorder with substantial
risk for long-term metabolic, cardiovascular, and renal morbidity and mortality, as well as …

Loss-of-function mutations of p16 INK4a have been identified in a large number of human
tumors. An established biochemical function of p16 is its ability to specifically inhibit cyclin D …

Fifteen independently isolated complementary DNA clones that contain T-cell receptor
(TCR) Vβ genes were sequenced and found to represent 11 different Vβ genes. When …

The variable-region (V) genes of the murine T-cell receptor beta chain exist largely as single-
element subfamilies. The V beta 5 and V beta 8 genes belong to the only two known three …

The antigen-specific receptors of T and B lymphocytes are distinct, though structurally
related, molecules. During development, lymphoid cells assemble functional variable (V) …

The complete germline organization of the β-chain genes of the murine T cell receptor was
elucidated in order to obtain the structural basis for understanding the mechanisms of …

Both cDNA and genomic clones of the T cell receptor (TCR) alpha‐and beta‐chain genes of
the alloreactive cytotoxic T lymphocyte (CTL) clone F3 were examined. Two distinct …