[HTML][HTML] Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions

M Snel, JT Jonker, J Schoones, H Lamb… - International journal of …, 2012 - hindawi.com
The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage.
Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the …

[PDF][PDF] Adipose tissue as an endocrine organ: im pact on insulin resistance

IM Jazet, H Pijl, A Meinders - The …, 2003 - scholarlypublications …
It is w ell know n that obesity is associated w ith insulin resistance and an increased risk for
type 2 diabetes mellitus. Formerly it w as postulated that increased lipolysis and …

Mechanisms in endocrinology: pathogenesis of type 2 diabetes in South Asians

LEH Bakker, MA Sleddering… - European journal of …, 2013 - academic.oup.com
The risk of developing type 2 diabetes mellitus (T2DM) is exceptionally high among both
native and migrant South Asians. T2DM occurs more often and at a younger age and lower …

Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function

S Hammer, M Snel, HJ Lamb, IM Jazet… - Journal of the American …, 2008 - jacc.org
Objectives: This study sought to assess the effects of prolonged caloric restriction in obese
patients with type 2 diabetes mellitus (T2DM) on myocardial triglyceride (TG) content and …

Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic

MM Ruissen, H Regeer, CP Landstra… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Introduction Lockdown measures have a profound effect on many aspects of daily life
relevant for diabetes self-management. We assessed whether lockdown measures, in the …

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study

LEH Bakker, MR Boon, RAD van der Linden… - The lancet Diabetes & …, 2014 - thelancet.com
Summary Background Individuals of south Asian origin have a very high risk of developing
type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity …

Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: the Netherlands epidemiology of …

R de Mutsert, K Gast, R Widya, E de Koning… - … syndrome and related …, 2018 - liebertpub.com
Background: Abdominal obesity is a well-established risk factor for the development of type
2 diabetes. However, sex differences may exist. We aimed to investigate the associations of …

[HTML][HTML] Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial

MB Bizino, IM Jazet, JJM Westenberg… - Cardiovascular …, 2019 - Springer
Background Liraglutide is an antidiabetic agent with cardioprotective effect. The purpose of
this study is to test efficacy of liraglutide to improve diabetic cardiomyopathy in patients with …

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1

EBM Nascimento, M Snel, B Guigas, GCM van der Zon… - Cellular signalling, 2010 - Elsevier
Type 2 diabetes is associated with alterations in protein kinase B (PKB/Akt) and mammalian
target of rapamycin complex 1 (mTORC1) signalling. The proline-rich Akt substrate of 40 …

[HTML][HTML] Supraclavicular Skin Temperature as a Measure of 18F-FDG Uptake by BAT in Human Subjects

MR Boon, LEH Bakker, RAD van der Linden… - PLoS …, 2014 - journals.plos.org
Background Brown adipose tissue (BAT) has emerged as a novel player in energy
homeostasis in humans and is considered a potential new target for combating obesity and …