Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …

Tumor cells undergoing the epithelial-mesenchymal transition (EMT) acquire the capacity to
migrate, invade the stroma and metastasize. EMT cells also acquire stem cell characteristics …

Metastatic spread of tumor cells to vital organs is the major cause of death in cancer.
Accumulating data support an important role of infiltrating immune cells in promoting …

Epithelial–mesenchymal transition (EMT) is essential for organogenesis and is triggered
during carcinoma progression to an invasive state. Transforming growth factor-β (TGF-β) …

Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue
homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding …

Tumors are composed of multiple cell types besides the tumor cells themselves, including
innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a …

Tumor cells frequently disseminate through the lymphatic system during metastatic spread of
breast cancer and many other types of cancer. Yet it is not clear how tumor cells make their …

Angiogenesis, the process by which new blood vessels arise from preexisting ones, is
critical for embryonic development and is an integral part of many disease processes …

During breast cancer progression, transforming growth factor-beta (TGF-β) switches from
acting as a growth inhibitor to become a major promoter of epithelial-mesenchymal …

The coxsackie-and adenovirus receptor (CAR) is a transmembrane protein belonging to the
immunoglobulin superfamily. The function of CAR as a virus receptor has been extensively …