Silica surface features and their role in the adsorption of biomolecules: computational modeling and experiments
There are many reasons to report on silica interacting with biomolecules. The most obvious
one is that on the Earth's crust, oxygen and silicon are the most abundant atomic species …
one is that on the Earth's crust, oxygen and silicon are the most abundant atomic species …
Adsorption and polymerization of amino acids on mineral surfaces: a review
JF Lambert - Origins of Life and Evolution of Biospheres, 2008 - Springer
The present paper offers a review of recent (post-1980) work on amino acid adsorption and
thermal reactivity on oxide and sulfide minerals. This review is performed in the general …
thermal reactivity on oxide and sulfide minerals. This review is performed in the general …
[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going
C Bellenguez, B Grenier-Boley, JC Lambert - Current Opinion in …, 2020 - Elsevier
Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …
[HTML][HTML] Rhythm control versus rate control for atrial fibrillation and heart failure
Background It is common practice to restore and maintain sinus rhythm in patients with atrial
fibrillation and heart failure. This approach is based in part on data indicating that atrial …
fibrillation and heart failure. This approach is based in part on data indicating that atrial …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …
previous studies; however, a large portion of the genetic risk for this disease remains …
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …
[HTML][HTML] TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras… - … England Journal of …, 2013 - Mass Medical Soc
Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …
receptor expressed on myeloid cells 2 protein, have previously been associated with an …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
[HTML][HTML] Histone recognition and large-scale structural analysis of the human bromodomain family
P Filippakopoulos, S Picaud, M Mangos, T Keates… - Cell, 2012 - cell.com
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …